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Opened 5 years ago
Last modified 5 years ago
#4241 assigned enhancement
Feature suggestion: combine focused cryo-EM maps
| Reported by: | Tristan Croll | Owned by: | Tom Goddard |
|---|---|---|---|
| Priority: | moderate | Milestone: | |
| Component: | Volume Data | Version: | |
| Keywords: | Cc: | ||
| Blocked By: | Blocking: | ||
| Notify when closed: | Platform: | all | |
| Project: | ChimeraX |
Description
I tried out the Phenix tool for this (https://www.phenix-online.org/documentation/reference/combine_focused_maps.html) a couple of days ago. It did a really nice job (combining seven ~3A cryo-EM maps of the same mitochondrial complex I structure - each focused on different parts of the complex - into a single weighted combination)... but it is sloo-ooo-ooow. For this case, it took around 4 hours - my intuitive expectation based on the complexity of the task was maybe a hundred times faster (i.e. a few minutes). Anyway, this seems to fit well within the scope of ChimeraX's core focus, and most of it seems to me like a simple combination of already-implemented functionality. The exception to that would be the need for a good estimation of local model-map correlation, since that's used to determine local weightings for each map.
Focused refinements are really common these days so I agree having a fast implementation would be nice. This would be a good feature to put in our R01 grant renewal.