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BRAF oncogenic mutants evade autoinhibition through a common mechanism. Lavoie H, Jin T et al. Science. 2025 May 29;388(6750):eadp2742.

MFSD6 is an entry receptor for enterovirus D68. Varanese L, Xu L et al. Nature. 2025 May 29;641(8065):1268–1275.

BMAL1-HIF2A heterodimer modulates circadian variations of myocardial injury. Ruan W, Li T et al. Nature. 2025 May 22;641(8064):1017-1028.

Glutamate gating of AMPA-subtype iGluRs at physiological temperatures. Kumar Mondal A, Carrillo E et al. Nature. 2025 May 15;641(8063):788–796.

Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis. Peng R, Xu X et al. Science. 2025 May 15;388(6748):eadq7597.

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News

May 7, 2025

The ChimeraX 1.10 release candidate is available – please try it and report any issues. See the change log for what's new.

March 19, 2025

Wiley most-cited-paper medallion
UCSF ChimeraX: Tools for structure building and analysis is one of the 10 most cited papers published in Protein Science in 2023!

March 1, 2025

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May 27, 2025

Biophysical Society 1-hr online tutorial: Biophysics101: Visualizing proteins with ChimeraX at 3pm Eastern (requires registration)

June 24, 2025

PDB101 1-hr online tutorial: Introduction to molecular animation at 1pm Eastern, 10am Pacific: (requires registration)


UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.

ChimeraX is developed with support from National Institutes of Health R01-GM129325.

Bluesky logo ChimeraX on Bluesky: @chimerax.ucsf.edu

Feature Highlight

Paired-10 palette
PuOr-5 palette

Color Palettes

A “palette” or ordered series of colors is used to color items sequentially (rainbow) or by values such as density. The ten chains in PDB 5o3l (paired tau filament) have been colored with the commands shown as 2D labels in the images. The first two examples at left use predefined palettes (credit to www.ColorBrewer.org, color specifications and designs by Cynthia A. Brewer, Pennsylvania State University), whereas the third shows specifying colors individually.

specified palette More features...

Example Image

HIV-1 protease B-factor coloring

B-factor Coloring

Atomic B-factor values are read from PDB and mmCIF input files and assigned as attributes that can be shown with coloring and used in atom specification. This example shows B-factor variation within a structure of the HIV-1 protease bound to an inhibitor (PDB 4hvp). For complete image setup, including positioning, color key, and label, see the command file bfactor.cxc.

Additional color key examples can be found in tutorials: Coloring by Electrostatic Potential, Coloring by Sequence Conservation

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