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Bacterial pathogen deploys the iminosugar glycosyrin to manipulate plant glycobiology. Sanguankiattichai N, Chandrasekar B et al. Science. 2025 Apr 18;388(6744):297-303.
Structure of human PINK1 at a mitochondrial TOM-VDAC array. Callegari S, Kirk NS et al. Science. 2025 Apr 18;388(6744):303-310.
Structural pathway for PI3-kinase regulation by VPS15 in autophagy. Cook ASI, Chen M et al. Science. 2025 Apr 11;388(6743):eadl3787.
A coronavirus assembly inhibitor that targets the viral membrane protein. Laporte M, Jochmans D et al. Nature. 2025 Apr 10;640(8058):514–523.
Cytoplasmic ribosomes on mitochondria alter the local membrane environment for protein import. Chang YT, Barad BA et al. J Cell Biol. 2025 Apr 7;224(4):e202407110.
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UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.
ChimeraX is developed with support from National Institutes of Health R01-GM129325.
Feature Highlight
A cryoelectron microscopy map of the 26S proteasome
(EMD-4321) is shown at the author-recommended contour level
in two different lighting modes: “simple” on the left
and “soft” on the right.
Soft lighting includes ambient lighting and shadowing (occlusion)
and can be turned on with the command
lighting soft
or by clicking the
Graphics
icon
For setup of the righthand image,
see the command file ambient.cxc.
Example Image
KCNQ1 is the pore-forming subunit of a cardiac potassium channel.
It binds to calmodulin, and mutations in either of these proteins
can cause congenital long QT syndrome, a dangerous
propensity for irregular heartbeats.
In the image, a structure of the KCNQ1/calmodulin complex
(PDB 5vms)
has been assembled into the native tetrameric form with the
sym command.
The view is from the cytoplasmic side, with
KCNQ1 shown as surfaces, calmodulin as cartoons, and calcium ions as balls.
A pastel palette
from ColorBrewer
has been used to color the surfaces, darkened with
color modify
for the cartoons, and “rotated” 45° in hue for the ions.
See the command file colormod.cxc.
cryoEM Ambient Occlusion
.
Potassium Channel-Calmodulin Complex
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