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A virally encoded tRNA neutralizes the PARIS antiviral defence system. Burman N, Belukhina S et al. Nature. 2024 Oct 10;634(8033):424–431.

Architecture and activation mechanism of the bacterial PARIS defence system. Deep A, Liang Q et al. Nature. 2024 Oct 10;634(8033):432–439.

Intragenic DNA inversions expand bacterial coding capacity. Chanin RB, West PT et al. Nature. 2024 Oct 3;634(8032):234–242.

Structural insights into the human P2X1 receptor and ligand interactions. Bennetts FM, Venugopal H et al. Nat Commun. 2024 Sep 28;15(1):8418.

Mutating a flexible region of the RSV F protein can stabilize the prefusion conformation. Liang Y, Shao S et al. Science. 2024 Sep 27;385(6716):1484-1491.

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News

October 14, 2024

Planned downtime: The ChimeraX website, Toolshed, web services (Blast Protein, Modeller, ...) and cgl.ucsf.edu e-mail will be unavailable starting Monday, Oct 14 10 AM PDT, continuing throughout the week and potentially the weekend (Oct 14-20).

August 1, 2024

Planned downtime: The ChimeraX website, Toolshed, web services (Blast Protein, Modeller, ...) and cgl.ucsf.edu e-mail will be unavailable August 1, 3-6 pm PDT.

June 17-18, 2024

Planned downtime: The ChimeraX website, Toolshed, web services (Blast Protein, Modeller, ...) and cgl.ucsf.edu e-mail will be unavailable June 17-18 PDT.

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UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.

ChimeraX is developed with support from National Institutes of Health R01-GM129325, Chan Zuckerberg Initiative grant EOSS4-0000000439, and the Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases.

Feature Highlight

simple lighting soft lighting

cryoEM Ambient Occlusion

A cryoelectron microscopy map of the 26S proteasome (EMD-4321) is shown at the author-recommended contour level in two different lighting modes: “simple” on the left and “soft” on the right. Soft lighting includes ambient lighting and shadowing (occlusion) and can be turned on with the command lighting soft or by clicking the Graphics icon .

For setup of the righthand image, see the command file ambient.cxc.

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Example Image

transducin switch regions

G-Protein Switch Regions

The GDP- and GTP-bound conformations of the transducin α-subunit (1tag and 1tnd, respectively) differ primarily in three regions, termed switch 1, switch 2, and switch 3. The structures have been superimposed with matchmaker and shown as cartoons, with “empty” outlines where the structures are almost the same (for simplicity, only one conformation's outlines are shown). The GTP analog GTPγS is displayed as spheres color-coded by heteroatom. For 2D labels and image setup other than structure orientation, see the command file switch.cxc.

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