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Targeting protein-ligand neosurfaces with a generalizable deep learning tool. Marchand A, Buckley S et al. Nature. 2025 Mar 13;639(8054):522–531.
Structural insights into RNA cleavage by PIWI Argonaute. Li Z, Xu Q et al. Nature. 2025 Mar 6;639(8053):250–259.
Plant pathogenic fungi hijack phosphate signaling with conserved enzymatic effectors. McCombe CL, Wegner A et al. Science. 2025 Feb 28;387(6737):955-962.
Antiviral signaling of a type III CRISPR-associated deaminase. Li Y, Li Z et al. Science. 2025 Feb 21;387(6736):eadr0393.
The structure of apolipoprotein B100 from human low-density lipoprotein. Berndsen ZT, Cassidy CK. Nature. 2025 Feb 20;638(8051):836–843.
More citations...News
December 25, 2024
|
December 12, 2024
The ChimeraX 1.9 production release is available! See the change log for what's new.
October 14, 2024
Planned downtime: The ChimeraX website, Toolshed, web services (Blast Protein, Modeller, ...) and cgl.ucsf.edu e-mail will be unavailable starting Monday, Oct 14 10 AM PDT, continuing throughout the week and potentially the weekend (Oct 14-20).
Previous news...Upcoming Events
UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.
ChimeraX is developed with support from National Institutes of Health R01-GM129325, Chan Zuckerberg Initiative grant EOSS4-0000000439, and the Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases.
Feature Highlight
Atomic structures and/or maps can be fit rigidly into other maps with the
Map
icon
, the
Fit in Map tool,
or the fitmap
command.
A common use is to locally optimize the fit after initial placement by hand.
The command includes options for symmetrical and sequential fitting,
as well as global search
to generate multiple starting points for local optimization.
Elongator is a highly conserved complex that associates with RNA polymerase II during transcriptional elongation. In the image, one of its six subunits, Elp2 (PDB 5m2n), has been fit into a map of the Elp123 subcomplex (EMDB 4151).
More features...Example Image
Calmodulin (CaM) acts as a calcium sensor. When its four Ca++ sites are fully occupied, it binds and modulates the activity of various downstream proteins, including CaM-dependent protein kinase I (CaMKI). Here, a complex between CaM and its target peptide from CaMKI (PDB 1mxe) is shown with cartoons, a transparent molecular surface, silhouette outlines, and light soft ambient occlusion. (If you prefer a less smudgy/rustic appearance, try using light gentle instead.) For image setup other than positioning, see the command file cam.cxc.
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