The RAD52 double-ring remodels replication forks restricting fork reversal. Honda M, Razzaghi M et al. Nature. 2025 May 8;641(8062):512–519.

Snapshots of acyl carrier protein shuttling in human fatty acid synthase. Schultz K, Costa-Pinheiro P et al. Nature. 2025 May 8;641(8062):520–528.

Structural dynamics of human fatty acid synthase in the condensing cycle. Choi W, Li C et al. Nature. 2025 May 8;641(8062):529–536.

Structural dynamics of DNA unwinding by a replicative helicase. Shahid T, Danazumi AU et al. Nature. 2025 May 1;641(8061):240–249.

Cryo-EM reveals mechanisms of natural RNA multivalency. Wang L, Xie J et al. Science. 2025 May 1;388(6746):545-550.

Base-modified nucleotides mediate immune signaling in bacteria. Zeng Z, Hu Z et al. Science. 2025 Apr 25;388(6745):eads6055.

Structural mechanism of LINE-1 target-primed reverse transcription. Ghanim GE, Hu H et al. Science. 2025 Apr 25;388(6745):eads8412.

Bacterial pathogen deploys the iminosugar glycosyrin to manipulate plant glycobiology. Sanguankiattichai N, Chandrasekar B et al. Science. 2025 Apr 18;388(6744):297-303.

Structure of human PINK1 at a mitochondrial TOM-VDAC array. Callegari S, Kirk NS et al. Science. 2025 Apr 18;388(6744):303-310.

Structural pathway for PI3-kinase regulation by VPS15 in autophagy. Cook ASI, Chen M et al. Science. 2025 Apr 11;388(6743):eadl3787.

A coronavirus assembly inhibitor that targets the viral membrane protein. Laporte M, Jochmans D et al. Nature. 2025 Apr 10;640(8058):514–523.

Cytoplasmic ribosomes on mitochondria alter the local membrane environment for protein import. Chang YT, Barad BA et al. J Cell Biol. 2025 Apr 7;224(4):e202407110.

Running a genetic stop sign accelerates oxygen metabolism and energy production in horses. Castiglione GM, Chen X et al. Science. 2025 Mar 28;387(6741):eadr8589.

Structural basis for the pore-forming activity of a complement-like toxin. Johnstone BA, Christie MP et al. Sci Adv. 2025 Mar 28;11(13):eadt2127.

Structure and mechanism of the Zorya anti-phage defence system. Hu H, Popp PF et al. Nature. 2025 Mar 27;639(8056):1093-1101.

Cryo-EM structures of a protein pore reveal a cluster of cholesterol molecules and diverse roles of membrane lipids. Šolinc G, Srnko M et al. Nat Commun. 2025 Mar 26;16(1):2972.

Genomic and structural insights into Jyvaskylavirus, the first giant virus isolated from Finland. Almeida GMF, Arriaga I et al. eLife. 2025 Mar 25;13:RP103492.

In-cell architecture of the mitochondrial respiratory chain. Waltz F, Righetto RD et al. Science. 2025 Mar 21;387(6740):1296-1301.

Structure and mechanism of vitamin-K-dependent γ-glutamyl carboxylase. Wang R, Chen B et al. Nature. 2025 Mar 20;639(8055):808–815.

Molecular basis of vitamin-K-driven γ-carboxylation at the membrane interface. Cao Q, Ammerman A et al. Nature. 2025 Mar 20;639(8055):816–824.

Evolutionary adaptations of doublet microtubules in trypanosomatid parasites. Doran MH, Niu Q et al. Science. 2025 Mar 14;387(6739):eadr5507.

Tunneling nanotube-like structures regulate distant cellular interactions during heart formation. Miao L, Lu Y et al. Science. 2025 Mar 14;387(6739):eadd3417.

Targeting protein-ligand neosurfaces with a generalizable deep learning tool. Marchand A, Buckley S et al. Nature. 2025 Mar 13;639(8054):522–531.

Structural insights into RNA cleavage by PIWI Argonaute. Li Z, Xu Q et al. Nature. 2025 Mar 6;639(8053):250–259.

High-resolution structures of Myosin-IC reveal a unique actin-binding orientation, ADP release pathway, and power stroke trajectory. Chavali SS, Carman PJ et al. Proc Natl Acad Sci USA. 2025 Mar 4;122(9):e2415457122.

Plant pathogenic fungi hijack phosphate signaling with conserved enzymatic effectors. McCombe CL, Wegner A et al. Science. 2025 Feb 28;387(6737):955-962.

Antiviral signaling of a type III CRISPR-associated deaminase. Li Y, Li Z et al. Science. 2025 Feb 21;387(6736):eadr0393.

The structure of apolipoprotein B100 from human low-density lipoprotein. Berndsen ZT, Cassidy CK. Nature. 2025 Feb 20;638(8051):836–843.

Passage of the HIV capsid cracks the nuclear pore. Kreysing JP, Heidari M et al. Cell. 2025 Feb 20;188(4):930-943.e21.

Bat genomes illuminate adaptations to viral tolerance and disease resistance. Morales AE, Dong Y et al. Nature. 2025 Feb 13;638(8050):449–458.

C-terminal amides mark proteins for degradation via SCF-FBXO31. Muhar MF, Farnung J et al. Nature. 2025 Feb 13;638(8050):519–527.

Resolving native GABA_A receptor structures from the human brain. Zhou J, Noviello CM et al. Nature. 2025 Feb 13;638(8050):562–568.

Four-component protein nanocages designed by programmed symmetry breaking. Lee S, Kibler RD et al. Nature. 2025 Feb 13;638(8050):546–552.

Structural basis of inhibition of human NaV1.8 by the tarantula venom peptide Protoxin-I. Neumann B, McCarthy S, Gonen S. Nat Commun. 2025 Feb 7;16(1):1459.

Crosslinking intermodular condensation in non-ribosomal peptide biosynthesis. Heberlig GW, La Clair JJ, Burkart MD. Nature. 2025 Feb 6;638(8049):261–269.

Conformational dynamics of a multienzyme complex in anaerobic carbon fixation. Yin MD, Lemaire ON et al. Science. 2025 Jan 31;387(6733):498-504.

Structural basis of H3K36 trimethylation by SETD2 during chromatin transcription. Markert JW, Soffers JH, Farnung L. Science. 2025 Jan 31;387(6733):528-533.

Novel lineage of anelloviruses with large genomes identified in dolphins. De Koch MD, Krupovic M et al. J Virol. 2025 Jan 31;99(1):e0137024.

Native DGC structure rationalizes muscular dystrophy-causing mutations. Liu S, Su T et al. Nature. 2025 Jan 30;637(8048):1261–1271.

Structural diversity of axonemes across mammalian motile cilia. Leung MR, Sun C et al. Nature. 2025 Jan 30;637(8048):1170-1177.

Conformational protection of molybdenum nitrogenase by Shethna protein II. Franke P, Freiberger S et al. Nature. 2025 Jan 23;637(8047):998–1004.

In situ analysis reveals the TRiC duty cycle and PDCD5 as an open-state cofactor. Xing H, Rosenkranz RRE et al. Nature. 2025 Jan 23;637(8047):983–990.

CRISPR-Cas12a bends DNA to destabilize base pairs during target interrogation. Soczek KM, Cofsky JC et al. Nucleic Acids Res. 2025 Jan 11;53(2):gkae1192.

Tracking transcription-translation coupling in real time. Qureshi NS, Duss O. Nature. 2025 Jan 9;637(8045):487–495.

Autoinhibition of dimeric NINJ1 prevents plasma membrane rupture. Pourmal S, Truong ME et al. Nature. 2025 Jan 9;637(8045):446–452.

Dual-action kinase inhibitors influence p38α MAP kinase dephosphorylation. Stadnicki EJ, Ludewig H et al. Proc Natl Acad Sci USA. 2025 Jan 7;122(1):e2415150122.

Chemical bond overlap descriptors from multiconfiguration wavefunctions. Santos-Jr CV, Kraka E, Moura RT Jr. J Comput Chem. 2025 Jan 5;46(1):e27534.

Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease. Fowler SL, Behr TS et al. Nat Neurosci. 2025 Jan;28(1):40-48.

Stereochemistry in the disorder-order continuum of protein interactions. Newcombe EA, Due AD et al. Nature. 2024 Dec 19;636(8043):762–768.

Apicomplexan mitoribosome from highly fragmented rRNAs to a functional machine. Wang C, Kassem S et al. Nat Commun. 2024 Dec 17;15(1):10689.

Composition and in situ structure of the Methanospirillum hungatei cell envelope and surface layer. Wang H, Zhang J et al. Sci Adv. 2024 Dec 13;10(50):eadr8596.

MCM double hexamer loading visualized with human proteins. Weissmann F, Greiwe JF et al. Nature. 2024 Dec 12;636(8042):499–508.

Multiple mechanisms for licensing human replication origins. Yang R, Hunker O et al. Nature. 2024 Dec 12;636(8042):488–498.

Molecular sociology of virus-induced cellular condensates supporting reovirus assembly and replication. Liu X, Xia X et al. Nat Commun. 2024 Dec 6;15(1):10638.

Broadly inhibitory antibodies to severe malaria virulence proteins. Reyes RA, Raghavan SSR et al. Nature. 2024 Dec 5;635(8041):182–189.

Anti-viral defence by an mRNA ADP-ribosyltransferase that blocks translation. Vassallo CN, Doering CR, Laub MT. Nature. 2024 Dec 5;635(8041):190–197.

Neutralizing antibodies elicited in macaques recognize V3 residues on altered conformations of HIV-1 Env trimer. DeLaitsch AT, Keeffe JR et al. NPJ Vaccines. 2024 Dec 5;9(1):240.

Conformational coupling between extracellular and transmembrane domains modulates holo-adhesion GPCR function. Kordon SP, Cechova K et al. Nat Commun. 2024 Dec 4;15(1):10545.

Molecular basis of mRNA delivery to the bacterial ribosome. Webster MW, Chauvier A et al. Science. 2024 Nov 29;386(6725):eado8476.

Design of customized coronavirus receptors. Liu P, Huang ML et al. Nature. 2024 Nov 28;635(8040):978–986.

Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes. Zhu X, Cruz VE et al. Science. 2024 Nov 22;386(6724):eadq8587.

Structure of the human TIP60-C histone exchange and acetyltransferase complex. Li C, Smirnova E et al. Nature. 2024 Nov 21;635(8039):764-769.

Archaeal type six secretion system mediates contact-dependent antagonism. Zachs T, Malit JJL et al. Sci Adv. 2024 Nov 15;10(46):eadp7088.

Quantifying constraint in the human mitochondrial genome. Lake NJ, Ma K et al. Nature. 2024 Nov 14;635(8038):390-397.

Engineered odorant receptors illuminate the basis of odour discrimination. de March CA, Ma N et al. Nature. 2024 Nov 14;635(8038):499–508.

Diverse anti-defence systems are encoded in the leading region of plasmids. Samuel B, Mittelman K et al. Nature. 2024 Nov 7;635(8037):186-192.

Transcriptome-wide splicing network reveals specialized regulatory functions of the core spliceosome. Rogalska ME, Mancini E et al. Science. 2024 Nov 1;386(6721):551-560.

The human ATAD5 has evolved unique structural elements to function exclusively as a PCNA unloader. Wang F, He Q et al. Struct Mol Biol. 2024 Nov;31(11):1680-1691

LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR. Bayly-Jones C, Lupton CJ et al. Nature. 2024 Oct 31;634(8036):1238–1244.

Glucose-sensitive insulin with attenuation of hypoglycaemia. Hoeg-Jensen T, Kruse T et al. Nature. 2024 Oct 24;634(8035):944-951.

A brain-to-gut signal controls intestinal fat absorption. Lyu Q, Xue W et al. Nature. 2024 Oct 24;634(8035):936-943.

Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP type C. Arseni D, Nonaka T et al. Nature. 2024 Oct 17;634(8034):662–668.

Structure of a fully assembled γδ T cell antigen receptor. Gully BS, Ferreira Fernandes J et al. Nature. 2024 Oct 17;634(8034):729–736.

A virally encoded tRNA neutralizes the PARIS antiviral defence system. Burman N, Belukhina S et al. Nature. 2024 Oct 10;634(8033):424–431.

Architecture and activation mechanism of the bacterial PARIS defence system. Deep A, Liang Q et al. Nature. 2024 Oct 10;634(8033):432–439.

Intragenic DNA inversions expand bacterial coding capacity. Chanin RB, West PT et al. Nature. 2024 Oct 3;634(8032):234–242.

Structural insights into the human P2X1 receptor and ligand interactions. Bennetts FM, Venugopal H et al. Nat Commun. 2024 Sep 28;15(1):8418.

Mutating a flexible region of the RSV F protein can stabilize the prefusion conformation. Liang Y, Shao S et al. Science. 2024 Sep 27;385(6716):1484-1491.

Structural insights into the high-affinity IgE receptor FcεRI complex. Deng M, Du S et al. Nature. 2024 Sep 26;633(8031):952–959.

Defining bottlenecks and opportunities for Lassa virus neutralization by structural profiling of vaccine-induced polyclonal antibody responses. Brouwer PJM, Perrett HR et al. Cell Rep. 2024 Sep 24;43(9):114708.

Large library docking identifies positive allosteric modulators of the calcium-sensing receptor. Liu F, Wu CG et al. Science. 2024 Sep 20;385(6715):eado1868.

Targeting cancer with small-molecule pan-KRAS degraders. Popow J, Farnaby W et al. Science. 2024 Sep 20;385(6715):1338-1347.

NAC guides a ribosomal multienzyme complex for nascent protein processing. Lentzsch AM, Yudin D et al. Nature. 2024 Sep 19;633(8030):718–724.

Mapping glycoprotein structure reveals Flaviviridae evolutionary history. Mifsud JCO, Lytras S et al. Nature. 2024 Sep 19;633(8030):695–703.

SymProFold: Structural prediction of symmetrical biological assemblies. Buhlheller C, Sagmeister T et al. Nat Commun. 2024 Sep 18;15(1):8152.

Inherent symmetry and flexibility in hepatitis B virus subviral particles. Wang Q, Wang T et al. Science. 2024 Sep 13;385(6714):1217-1224.

Substrate binding and inhibition mechanism of norepinephrine transporter. Ji W, Miao A et al. Nature. 2024 Sep 12;633(8029):473–479.

In situ structure and rotary states of mitochondrial ATP synthase in whole Polytomella cells. Dietrich L, Agip AA et al. Science. 2024 Sep 6;385(6713):1086-1090.

Structural basis for transthiolation intermediates in the ubiquitin pathway. Kochańczyk T, Hann ZS et al. Nature. 2024 Sep 5;633(8028):216–223.

Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site. Caniels TG, Medina-Ramìrez M et al. Sci Immunol. 2024 Aug 30;9(98):eadk9550.

Cultivation and visualization of a methanogen of the phylum Thermoproteota. Kohtz AJ, Petrosian N et al. Nature. 2024 Aug 29;632(8027):1118–1123.

Structural insights into the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex. Yang Z, Mameri A et al. Science. 2024 Aug 23;385(6711):eadl5816.

De novo design of allosterically switchable protein assemblies. Pillai A, Idris A et al. Nature. 2024 Aug 22;632(8026):911–920.

Molecular basis of human noradrenaline transporter reuptake and inhibition. Tan J, Xiao Y et al. Nature. 2024 Aug 22;632(8026):921–929.

Generative artificial intelligence performs rudimentary structural biology modeling. Ille AM, Markosian C et al. Sci Rep. 2024 Aug 21;14(1):19372.

Atomic structures of a bacteriocin targeting Gram-positive bacteria. Cai X, He Y et al. Nat Commun. 2024 Aug 16;15(1):7057.

Structure and inhibition of SARS-CoV-2 spike refolding in membranes. Grunst MW, Qin Z et al. Science. 2024 Aug 16;385(6710):757-765.

Structure of the human dopamine transporter in complex with cocaine. Nielsen JC, Salomon K et al. Nature. 2024 Aug 15;632(8025):678-685.

Mechanism of allosteric inhibition of human p97/VCP ATPase and its disease mutant by triazole inhibitors. Nandi P, DeVore K et al. Commun Chem. 2024 Aug 9;7(1):177.

Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants. Kim ED, Wu X et al. Nature. 2024 Aug 8;632(8024):451–459.