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Mechanism of DNA targeting by human LINE-1. Jin W, Yu C et al. Science. 2025 Oct 9;390(6769):eadu3433.

GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling. Zhou C, Zhang M et al. Science. 2025 Oct 2;390(6768):eads8728.

Elucidating the structure and assembly mechanism of actinoporin pores in complex membrane environments. Arranz R, Santiago C et al. Sci Adv. 2025 Sep 26;11(39):eadv0683.

The molecular infrastructure of glutamatergic synapses in the mammalian forebrain. Peukes J, Lovatt C et al. eLife. 2025 Sep 25;13:RP100335.

Structural remodeling of target-SNARE protein complexes by NSF enables synaptic transmission. White KI, Khan YA et al. Nat Commun. 2025 Sep 24;16(1):8371.

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News

September 22, 2025

Mac users may wish to defer upgrading to MacOS Tahoe. Currently on that OS the Chimera graphics window is shifted so that it covers the command and status lines.

March 6, 2025

Chimera production release 1.19 is now available, fixing the ability to fetch structures from the PDB (details...).

December 25, 2024

The RBVI wishes you a safe and happy holiday season! See our 2024 card and the gallery of previous cards back to 1985.

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Upcoming Events

Please note that UCSF Chimera is legacy software that is no longer being developed or supported. Users are strongly encouraged to try UCSF ChimeraX, which is under active development.

UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.

We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features in addition to nearly all the capabilities of Chimera (details...).

Chimera is no longer under active development. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.

Feature Highlight

volume plane topography

Topography

Values in a plane of volume data can be shown as heights normal to the plane (a topographic map). When a single plane is displayed with Volume Viewer, the command topography will plot the values as heights in a surface.

(More features...)

Gallery Sample

Orexin Receptor Complex

The image shows the structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant, Protein Data Bank entry 4s0v. The drug is shown as spheres colored by element, and the receptor as ribbons with secondary structure elements rainbow-colored from blue at the N-terminus to red at the C-terminus. (More samples...)


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