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Structure of the ATP-driven methyl-coenzyme M reductase activation complex. Ramírez-Amador F, Paul S et al. Nature. 2025 Jun 19;642(8068):814–821.

Lewy-MSA hybrid fold drives distinct neuronal α-synuclein pathology. Enomoto M, Martinez-Valbuena I et al. Commun Biol. 2025 Jun 16;8(1):929.

Small molecules restore mutant mitochondrial DNA polymerase activity. Valenzuela S, Zhu X et al. Nature. 2025 Jun 12;642(8067):501–507.

PLA2G15 is a BMP hydrolase and its targeting ameliorates lysosomal disease. Nyame K, Xiong J et al. Nature. 2025 Jun 12;642(8067):474–483.

Complex water networks visualized by cryogenic electron microscopy of RNA. Kretsch RC, Li S et al. Nature. 2025 Jun 5;642(8066):250–259.

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News

June 26, 2025

The ChimeraX 1.10 production release is available! See the change log for what's new.

May 7, 2025

The ChimeraX 1.10 release candidate is available – please try it and report any issues. See the change log for what's new.

March 19, 2025

Wiley most-cited-paper medallion
UCSF ChimeraX: Tools for structure building and analysis is one of the 10 most cited papers published in Protein Science in 2023!

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UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.

ChimeraX is developed with support from National Institutes of Health R01-GM129325.

Bluesky logo ChimeraX on Bluesky: @chimerax.ucsf.edu

Feature Highlight

simple lighting soft lighting

cryoEM Ambient Occlusion

A cryoelectron microscopy map of the 26S proteasome (EMD-4321) is shown at the author-recommended contour level in two different lighting modes: “simple” on the left and “soft” on the right. Soft lighting includes ambient lighting and shadowing (occlusion) and can be turned on with the command lighting soft or by clicking the Graphics icon .

For setup of the righthand image, see the command file ambient.cxc.

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Example Image

HIV-1 protease B-factor coloring

B-factor Coloring

Atomic B-factor values are read from PDB and mmCIF input files and assigned as attributes that can be shown with coloring and used in atom specification. This example shows B-factor variation within a structure of the HIV-1 protease bound to an inhibitor (PDB 4hvp). For complete image setup, including positioning, color key, and label, see the command file bfactor.cxc.

Additional color key examples can be found in tutorials: Coloring by Electrostatic Potential, Coloring by Sequence Conservation

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