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Recent Citations

Chanoclavine synthase operates by an NADPH-independent superoxide mechanism. Chen CC, Yu ZP et al. Nature. 2025 Apr 17;640(8059):840-846.

A small-molecule SARS-CoV-2 inhibitor targeting the membrane protein. Van Damme E, Abeywickrema P et al. Nature. 2025 Apr 10;640(8058):506–513.

The conserved HIV-1 spacer peptide 2 triggers matrix lattice maturation. Stacey JCV, Hrebík D et al. Nature. 2025 Apr 3;640(8057):258–264.

Structural insights into lipid chain-length selectivity and allosteric regulation of FFA2. Kugawa M, Kawakami K et al. Nat Commun. 2025 Mar 26;16(1):2809.

Molecular architectures of centrosomes in C. elegans embryos visualized by cryo-electron tomography. Tollervey F, Rios MU et al. Dev Cell. 2025 Mar 24;60(6):885-900.e5.

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March 6, 2025

Chimera production release 1.19 is now available, fixing the ability to fetch structures from the PDB (details...).

December 25, 2024

The RBVI wishes you a safe and happy holiday season! See our 2024 card and the gallery of previous cards back to 1985.

October 14, 2024

Planned downtime: The Chimera and ChimeraX websites, web services (Blast Protein, Modeller, ...) and cgl.ucsf.edu e-mail will be unavailable starting Monday, Oct 14 10 AM PDT, continuing throughout the week and potentially the weekend (Oct 14-20).

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Upcoming Events

Please note that UCSF Chimera is legacy software that is no longer being developed or supported. Users are strongly encouraged to try UCSF ChimeraX, which is under active development.

UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.

We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features in addition to nearly all the capabilities of Chimera (details...).

Chimera is no longer under active development. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.

Feature Highlight

ribbon spline comparison

Ribbon Spline Options

The default ribbon path is a smooth bspline (semitransparent tan in the figure), which can diverge from the true positions of the backbone atoms (α-carbons shown as gray balls). A cardinal spline allows tracking the backbone more closely. Without smoothing (light blue), it follows the α-carbons exactly, or it can be combined with some “compromise” smoothing of strand and/or coil. Ribbon spline options can be set with the ribspline command or in the molecule model attributes.

(More features...)

Gallery Sample

Orexin Receptor Complex

The image shows the structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant, Protein Data Bank entry 4s0v. The drug is shown as spheres colored by element, and the receptor as ribbons with secondary structure elements rainbow-colored from blue at the N-terminus to red at the C-terminus. (More samples...)


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