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LetA defines a structurally distinct transporter family. Santarossa CC, Li Y et al. Nature. 2026 Mar 26;651(8107):1097–1106.

Psychedelics elicit their effects by 5-HT(2A) receptor-mediated G(i) signalling. Xu Z, Wang H et al. Nature. 2026 Mar 19;651(8106):829–837.

Polymerase trapping as the mechanism of H5 highly pathogenic avian influenza virus genesis. Funk M, Spronken MI et al. Science. 2026 Mar 12;391(6790):eadr6632.

Identification of an allosteric site on the E3 ligase adapter cereblon. Dippon VN, Rizvi Z et al. Nature. 2026 Mar 12;651(8105):482-490.

Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress. Ehses K, López-Alonso JP et al. Sci Adv. 2026 Mar 6;12(10):eaed3579.

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December 25, 2025

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The RBVI wishes you a safe and happy holiday season! See our 2025 card and the gallery of previous cards back to 1985.

September 22, 2025

Mac users may wish to defer upgrading to MacOS Tahoe. Currently on that OS the Chimera graphics window is shifted so that it covers the command and status lines.

March 6, 2025

Chimera production release 1.19 is now available, fixing the ability to fetch structures from the PDB (1.19 release notes).

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Please note that UCSF Chimera is legacy software that is no longer being developed or supported. Users are strongly encouraged to try UCSF ChimeraX, which is under active development.
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UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.

We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features in addition to nearly all the capabilities of Chimera (details...).

Chimera is no longer under active development. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.

Feature Highlight

pipes & planks

Pipes and Planks

The PipesAndPlanks tool shows protein helices as “pipes” (cylinders) and strands as “planks” (rectangular boxes), with connectors for the intervening coil. Adjustable settings include pipe radius, plank width, colors, and whether to include arrowheads to show chain N→C directionality (see image how-to).

(More features...)

Gallery Sample

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Neuraminidase Flowers

The image shows tetramers of influenza neuraminidase (Protein Data Bank entry 3k3a) styled as flowers. Three tetramers are colored pink, with a central metal ion in white and nearby residues in yellow, and a fourth tetramer is colored green to resemble leaves. Each monomer or “petal” is a six-bladed β-propeller. (More samples...)


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