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Recent Citations

Regulation of STING activation by phosphoinositide and cholesterol. Li J, Tan JX et al. Nature. 2026 Apr 9;652(8109):499–507.

eT 2.0: An efficient open-source molecular electronic structure program. Folkestad SD, Kjønstad EF et al. J Chem Phys. 2026 Apr 7;164(13):132501.

Microtubules guide Aurora B substrate geometries for accurate chromosome segregation. Niu Y, DeLuca KF et al. Sci Adv. 2026 Mar 27;12(13):eaea2112.

Discovery and cryoEM structure of FPM13, a periplasmic metalloprotein unique to Francisella. Clemens DL, Lee BY et al. PLoS Pathog. 2026 Mar 27;22(3):e1014024.

LetA defines a structurally distinct transporter family. Santarossa CC, Li Y et al. Nature. 2026 Mar 26;651(8107):1097–1106.

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News

December 25, 2025

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The RBVI wishes you a safe and happy holiday season! See our 2025 card and the gallery of previous cards back to 1985.

September 22, 2025

Mac users may wish to defer upgrading to MacOS Tahoe. Currently on that OS the Chimera graphics window is shifted so that it covers the command and status lines.

March 6, 2025

Chimera production release 1.19 is now available, fixing the ability to fetch structures from the PDB (1.19 release notes).

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Please note that UCSF Chimera is legacy software that is no longer being developed or supported. Users are strongly encouraged to try UCSF ChimeraX, which is under active development.
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UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.

We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features in addition to nearly all the capabilities of Chimera (details...).

Chimera is no longer under active development. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.

Feature Highlight

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Multiple Sequence Alignment

Multiple sequence alignment of structure chains in Chimera or realignment of the sequences in an existing alignment can be performed using web services hosted by the UCSF RBVI. The following programs are provided:

The result is automatically shown in Multalign Viewer. (Sequences can also be added to an alignment one by one without a web service, but true multiple sequence alignment is often advantageous.) (More features...)

Gallery Sample

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Sliced Potassium Channel

Potassium channel (Protein Data Bank entry 1bl8) on a dark slate blue background with potassium ions shown in firebrick. The channel is comprised of four chains. Each chain has been rainbow-colored from blue at the N-terminus to red at the C-terminus, but only the surface of the channel is shown. The surface has been sliced with a per-model clipping plane. The surface cap color is plum except with opacity set to 0.8. The shininess and brightness have been set to 128 and 8, respectively, and the lights on the scene have been moved from their default positions. The subdivision quality (related to the smoothness of the spherical ions) is 5.0, and the molecular surface was computed with probe radius and vertex density set to 1.0 and 6.0, respectively. (More samples...)


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