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SPARC: a structural pathogenicity algorithm for risk classification of hERG variants. Chatelain FC, de Oliveira BR et al. Europace. 2026 Feb 3;28(2):euaf327.
Cryo-EM structure of the vaccinia virus entry fusion complex reveals a multicomponent fusion machinery. Lin CS, Li CA et al. Sci Adv. 2026 Jan 16;12(3):eaec0254.
Toward community-driven visual proteomics with large-scale cryo-electron tomography of Chlamydomonas reinhardtii. Kelley R, Khavnekar S et al. Mol Cell. 2026 Jan 8;86(1):213-230.e7.
Structural insights into the activation mechanism of the human metabolite receptor HCAR1. Gao M, Zang S et al. Sci Signal. 2026 Jan 6;19(919):eadw1483.
Crystal structure of Methanococcus jannaschii dihydroorotase with substrate bound. Vitali J, Nix JC et al. Acta Crystallogr F Struct Biol Commun. 2026 Jan 1;82(Pt 1):23-31.
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December 25, 2025
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September 22, 2025
Mac users may wish to defer upgrading to MacOS Tahoe. Currently on that OS the Chimera graphics window is shifted so that it covers the command and status lines.
March 6, 2025
Chimera production release 1.19 is now available, fixing the ability to fetch structures from the PDB (1.19 release notes).
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UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.
We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features in addition to nearly all the capabilities of Chimera (details...).
Chimera is no longer under active development. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.
Feature Highlight
Amino acid sidechains adopt different conformational states, or rotamers. Rotamers from the Dunbrack backbone-dependent library or the Richardson "penultimate" library can be viewed, evaluated, and incorporated into structures with the Rotamers tool. A residue can be changed into a different conformation of the same type of amino acid or mutated into a different type. Rotamer torsion angles and library probability values are listed in a dialog, along with (optionally) hydrogen bonds, clashes, and agreement with electron density data. Only rotamers chosen in the list are displayed. When a single rotamer is chosen, it can be incorporated into the structure. The image includes 2D labels.
(More features...)
Gallery Sample
Peroxiredoxins are enzymes that help cells cope with stressors such as high levels of reactive oxygen species. The image shows a decameric peroxiredoxin from human red blood cells (Protein Data Bank entry 1qmv), styled as a holiday wreath.
See also the RBVI holiday card gallery.
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