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A MERS-CoV-like mink coronavirus uses ACE2 as an entry receptor. Wang N, Ji W et al. Nature. 2025 Jun 19;642(8068):739–746.
Cryo-EM reveals structural diversity in prolate-headed mycobacteriophage Mycofy1. Li X, Shao Q et al. J Mol Biol. 2025 Jun 15;437(12):169126.
Conformational cycle and small-molecule inhibition mechanism of a plant ABCB transporter in lipid membranes. Liu Y, Liao M. Sci Adv. 2025 Jun 13;11(24):eadv9721.
Cat1 forms filament networks to degrade NAD+ during the type III CRISPR-Cas antiviral response. Baca CF, Majumder P et al. Science. 2025 Jun 12;388(6752):eadv9045.
Swinging lever mechanism of myosin directly shown by time-resolved cryo-EM. Klebl DP, McMillan SN et al. Nature. 2025 Jun 12;642(8067):519–526.
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March 6, 2025
Chimera production release 1.19 is now available, fixing the ability to fetch structures from the PDB (details...).
December 25, 2024
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October 14, 2024
Planned downtime: The Chimera and ChimeraX websites, web services (Blast Protein, Modeller, ...) and cgl.ucsf.edu e-mail will be unavailable starting Monday, Oct 14 10 AM PDT, continuing throughout the week and potentially the weekend (Oct 14-20).
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UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.
We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features in addition to nearly all the capabilities of Chimera (details...).
Chimera is no longer under active development. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.
Feature Highlight
Structures and their pocket measurements can be fetched directly from the Computed Atlas of Surface Topography of proteins (CASTp) database or read from local files previously returned by the CASTp server. In Chimera, the pockets are shown in a pocket list. Choosing rows in the list performs actions such as zooming in on pockets and selecting the surrounding atoms.
The figure shows the four largest pockets by volume identified by CASTp for PDB entry 1ovh (a cavity mutant of T4 lysozyme), shown in yellow, orange, pink, and magenta in order of decreasing volume. The largest is lysozyme's active site, with two openings. The second largest is the engineered cavity. Mutated positions are shown in red. Green balls are Cl– ions.
(More features...)Gallery Sample
Peroxiredoxins are enzymes that help cells cope with stressors such as high levels of reactive oxygen species. The image shows a decameric peroxiredoxin from human red blood cells (Protein Data Bank entry 1qmv), styled as a holiday wreath.
See also the RBVI holiday card gallery.
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