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Featured Citations

Cryo-EM structure of the Ebola virus nucleoprotein-RNA complex at 3.6 Å resolution. Sugita Y, Matsunami H et al. Nature. 2018 Nov 1;563(7729):137-140.

Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes. Ramrath DJF, Niemann M et al. Science. 2018 Oct 26;362(6413). pii: eaau7735.

Molecular visualization on the holodeck. Goddard TD, Brilliant AA et al. J Mol Biol. 2018 Oct 19;430(21):3982-3996.

Structural basis of the filamin A actin-binding domain interaction with F-actin. Iwamoto DV, Huehn A et al. Nat Struct Mol Biol. 2018 Oct;25(10):918-927.

Structure of the membrane-assembled retromer coat determined by cryo-electron tomography. Kovtun O, Leneva N et al. Nature. 2018 Sep 27;561(7724):561-564.

See also: RCSB PDB Images
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News

August 7, 2018

ChimeraX version 0.7 is available. See the change log for what's new.

July 13, 2018

New Virtual Reality at UCSF website shares information on VR projects, resources, and related issues.

April 6, 2018

ChimeraX version 0.6 is available. See the change log for what's new.

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UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see licensing.

ChimeraX development is supported in part by grants from the National Institutes of Health (currently R01-GM129325, previously P41-GM103311).

Feature Highlight

DNA/protein complex with struts

Struts for 3D Printing

Structures can be reinforced for 3D printing with pseudobonds. In this DNA-transcription factor complex (PDB 5ego), proteins are shown as ribbons and the DNA as a molecular surface. The pseudobonds in blue were read in from a manually created file, 5ego.pb, and further reinforcements in light gray were added automatically with the struts command. For image setup other than orientation, see the command file struts.cxc.

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Example Image

cyclodextrin pore

Cyclodextrin Pore

The outer-membrane protein CymA admits bulky molecules into the periplasmic space of Klebsiella oxytoca. Here, CymA (PDB 4d5d chain A) is depicted in a style reminiscent of a diagnostic X-ray, with transparent molecular surface and β-strand “ribs” in white. The protein has ingested α-cyclodextrin (top) and β-cyclodextrin (bottom), bound at the entry site and near the exit, respectively. Cyclodextrin carbon atoms are shown in blue-gray and oxygen atoms in brick red. For image setup, see the command file xray.cxc.

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