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Featured Citations

90S pre-ribosome transformation into the primordial 40S subunit. Cheng J, Lau B et al. Science. 2020 Sep 18;369(6510):1470-1476.

Structure of a human 48S translational initiation complex. Brito Querido J, Sokabe M et al. Science. 2020 Sep 4;369(6508):1220-1227.

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2. Thoms M, Buschauer R et al. Science. 2020 Sep 4;369(6508):1249-1255.

Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A. Ni T, Gerard S et al. Nat Struct Mol Biol. 2020 Sep;27(9):846–854.

Structures of human pannexin 1 reveal ion pathways and mechanism of gating. Ruan Z, Orozco IJ et al. Nature. 2020 Aug 27;584(7822):646-651.

See also: RCSB PDB Images
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News

September 10, 2020

The ChimeraX 1.1 production release is available. See the change log for what's new.

August 27, 2020

The ChimeraX 1.1 release candidate is available. Please try it and report any issues. See the change log for what's new.

June 11, 2020

The ChimeraX 1.0 production release is available! See the change log for what it contains.

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UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see licensing.

ChimeraX is developed with support from National Institutes of Health R01-GM129325 and the Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases.

Feature Highlight

man and molecule

Virtual Reality

ChimeraX virtual reality works with HTC Vive, Oculus Rift, and Samsung Odyssey systems (those supported by SteamVR). Any structures, maps, etc. that can be displayed in ChimeraX can be viewed in the headset and manipulated with the hand controllers. Icon toolbars visible in the headset allow changing the scene display or hand-controller button assignments with a single click. Besides rotation, translation, and zooming, useful functions include labeling, distance measurement, bond rotation, placing markers into a map, and changing map contour levels. Virtual-reality (VR) mode can be turned on and off with the vr command, and the meeting command allows multiple users to share a single session in VR.

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Example Image

neuraminidase flowers

Potassium Channel-Calmodulin Complex

KCNQ1 is the pore-forming subunit of a cardiac potassium channel. It binds to calmodulin, and mutations in either of these proteins can cause congenital long QT syndrome, a dangerous propensity for irregular heartbeats. In the image, a structure of the KCNQ1/calmodulin complex (PDB 5vms) has been assembled into the native tetrameric form with the sym command. The view is from the cytoplasmic side, with KCNQ1 shown as surfaces, calmodulin as cartoons, and calcium ions as balls. A pastel palette from ColorBrewer has been used to color the surfaces, darkened with color modify for the cartoons, and “rotated” 45° in hue for the ions. See the command file colormod.cxc.

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