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Featured Citations

Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody. Pinto D, Park YJ et al. Nature. 2020 Jul 9;583(7815):290-295.

How IGF-II binds to the human type 1 insulin-like growth factor receptor. Xu Y, Kirk NS et al. Structure. 2020 Jul 7;28(7):786-798.e6.

Electromechanical coupling in the hyperpolarization-activated K+ channel KAT1. Clark MD, Contreras GF et al. Nature. 2020 Jul 2;583(7814):145-149.

Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-β fibrils. Röder C, Kupreichyk T et al. Nat Struct Mol Biol. 2020 Jul;27(7):660-667.

Cryo-EM structure of the human cohesin-NIPBL-DNA complex. Shi Z, Gao H et al. Science. 2020 Jun 26;368(6498):1454-1459.

See also: RCSB PDB Images
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News

June 11, 2020

The ChimeraX 1.0 production release is available! See the change log for what it contains.

May 8, 2020

We have joined the Twitterverse! – @UCSFChimeraX

May 6, 2020

The ChimeraX 1.0 release candidate is available! Please try it and report any issues. See the change log for what's new.

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UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see licensing.

ChimeraX is developed with support from National Institutes of Health R01-GM129325 and the Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases.

Feature Highlight

Elp2 fit into map of Elongator subcomplex

Fitting to Density Maps

Atomic structures and/or maps can be fit rigidly into other maps with the Map icon , the Fit in Map tool, or the fitmap command. A common use is to locally optimize the fit after initial placement by hand. The command includes options for symmetrical and sequential fitting, as well as global search to generate multiple starting points for local optimization.

Elongator is a highly conserved complex that associates with RNA polymerase II during transcriptional elongation. In the image, one of its six subunits, Elp2 (PDB 5m2n), has been fit into a map of the Elp123 subcomplex (EMDB 4151).

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Example Image

neuraminidase flowers

Potassium Channel-Calmodulin Complex

KCNQ1 is the pore-forming subunit of a cardiac potassium channel. It binds to calmodulin, and mutations in either of these proteins can cause congenital long QT syndrome, a dangerous propensity for irregular heartbeats. In the image, a structure of the KCNQ1/calmodulin complex (PDB 5vms) has been assembled into the native tetrameric form with the sym command. The view is from the cytoplasmic side, with KCNQ1 shown as surfaces, calmodulin as cartoons, and calcium ions as balls. A pastel palette from ColorBrewer has been used to color the surfaces, darkened with color modify for the cartoons, and “rotated” 45° in hue for the ions. See the command file colormod.cxc.

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