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Featured Citations

ArtiaX: An electron tomography toolbox for the interactive handling of sub-tomograms in UCSF ChimeraX. Ermel UH, Arghittu SM, Frangakis AS. Protein Sci. 2022 Dec;31(12):e4472.

Structural principles of B cell antigen receptor assembly. Dong Y, Pi X et al. Nature. 2022 Dec 1;612(7938):156–161.

Starting a new chapter on class Ia ribonucleotide reductases. Levitz TS, Drennan CL. Curr Opin Struct Biol. 2022 Dec;77:102489.

Structural basis for mechanotransduction in a potassium-dependent mechanosensitive ion channel. Mount J, Maksaev G et al. Nat Commun. 2022 Nov 12;13(1):6904.

Cryo-EM structure of the SEA complex. Tafur L, Hinterndorfer K et al. Nature. 2022 Nov 10;611(7935):399–404.

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News

November 23, 2022

The ChimeraX 1.5 production release is available! See the change log for what's new.

October 13, 2022

The ChimeraX 1.5 release candidate is available! Please try it and report any issues. See the change log for what's new.

September 27, 2022

Website downtime: The RBVI website (Chimera, ChimeraX, etc.) and RBVI-hosted web services will be down for maintenance from Tue, Sep 27 9pm PDT, through Wed, possibly extending to Thu, Sep 29 5pm PDT.

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UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.

ChimeraX is developed with support from National Institutes of Health R01-GM129325, Chan Zuckerberg Initiative grant EOSS4-0000000439, and the Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases.

Feature Highlight

multichannel 3D image of hiPSCs from AICS

Multichannel Light Microscopy

3D images and time series from multichannel optical microscopy are shown in the Volume Viewer tool, with easy access to hiding/showing individual channels, changing their colors, and adjusting threshold levels with the mouse. The menu of style options includes “volume” (translucent blobs, as in the image), surface, mesh, maximum intensity projection, single plane, and orthoplanes. For convenience, the step size, region bounds, and display style of different channels of the same dataset are coupled, in that changing the setting of one channel automatically changes it for the others.

The image shows human induced pluripotent stem cells, with plasma membrane in violet red, EGFP-tagged fibrillarin (as a marker for nucleolus) in yellow, and DNA (nucleus) in turquoise. The data are publicly available from the Allen Cell Explorer website, dataset: AICS-14_0.

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Example Image

HIV-1 protease B-factor coloring

B-factor Coloring

Atomic B-factor values are read from PDB and mmCIF input files and assigned as attributes that can be shown with coloring and used in atom specification. This example shows B-factor variation within a structure of the HIV-1 protease bound to an inhibitor (PDB 4hvp). For complete image setup, including positioning, color key, and label, see the command file bfactor.cxc.

Additional color key examples can be found in tutorials: Coloring by Electrostatic Potential, Coloring by Sequence Conservation

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