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Featured Citations

Structural insights into preinitiation complex assembly on core promoters. Chen X, Qi Y et al. Science. 2021 Apr 30;372(6541):eaba8490.

Structural insights into the lipid and ligand regulation of serotonin receptors. Xu P, Huang S et al. Nature. 2021 Apr 15;592(7854):469-473.

Structure of the human Mediator-bound transcription preinitiation complex. Abdella R, Talyzina A et al. Science. 2021 Apr 2;372(6537):52-56.

Structure-based decoupling of the pro- and anti-inflammatory functions of interleukin-10. Saxton RA, Tsutsumi N et al. Science. 2021 Mar 19;371(6535):eabc8433.

Architecture and structural dynamics of the heteromeric GluK2/K5 kainate receptor. Khanra N, Brown PM et al. eLife. 2021 Mar 16;10:e66097.

See also: RCSB PDB Images
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News

December 11, 2020

The RBVI wishes you a safe and happy holiday season! See our 2020 card and the gallery of previous cards back to 1985.

November 4, 2020

New paper online: UCSF ChimeraX: Structure visualization for researchers, educators, and developers. Pettersen EF, Goddard TD, et al. Protein Sci. 2020, in press.

September 23, 2020

Mac users: ChimeraX v1.1 does not work on MacOS 11.0 (Big Sur), but this problem has been fixed in v1.1.1 and the daily build.

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UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.

ChimeraX is developed with support from National Institutes of Health R01-GM129325 and the Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases.

Feature Highlight

multichannel 3D image of hiPSCs from AICS

Multichannel Light Microscopy

3D images and time series from multichannel optical microscopy are shown in the Volume Viewer tool, with easy access to hiding/showing individual channels, changing their colors, and adjusting threshold levels with the mouse. The menu of style options includes “volume” (translucent blobs, as in the image), surface, mesh, maximum intensity projection, single plane, and orthoplanes. For convenience, the step size, region bounds, and display style of different channels of the same dataset are coupled, in that changing the setting of one channel automatically changes it for the others.

The image shows human induced pluripotent stem cells, with plasma membrane in violet red, EGFP-tagged fibrillarin (as a marker for nucleolus) in yellow, and DNA (nucleus) in turquoise. The data are publicly available from the Allen Cell Explorer website, dataset: AICS-14_0.

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Example Image

The Human Ribosome

The architecture of the human ribosome has been determined at near-atomic resolution by electron microscopy (Anger et al., Nature 497:80 (2013)). The structure, comprising 82 proteins and five RNA molecules, is shown with shadows cast from all directions to accentuate depth. In the background are schematic representations of contacts between the component molecules.

See the image setup script card.cxc using the 'Tis the Season color palette (credit to MrsP). See also the RBVI holiday card gallery.

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