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Citations (partial list)

Structural pharmacology and therapeutic potential of 5-methoxytryptamines. Warren AL, Lankri D et al. Nature. 2024 Jun 6;629(8015):237–246.

Observation of a promethium complex in solution. Driscoll DM, White FD et al. Nature. 2024 May 23;629(8013):819-823.

Stepwise activation of a metabotropic glutamate receptor. Krishna Kumar K, Wang H et al. Nature. 2024 May 23;629(8013):951–956.

Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1. Son Y, Kenny TC et al. Nature. 2024 May 16;629(8012):710–716.

Structural and molecular basis of choline uptake into the brain by FLVCR2. Cater RJ, Mukherjee D et al. Nature. 2024 May 16;629(8012):704–709.

Growth phase-dependent reorganization of cryptophyte photosystem I antennae. Zhang S, Si L et al. Commun Biol. 2024 May 11;7(1):560.

Promiscuous G-protein activation by the calcium-sensing receptor. Zuo H, Park J et al. Nature. 2024 May 9;629(8011):481–488.

Structural insights into vesicular monoamine storage and drug interactions. Ye J, Chen H et al. Nature. 2024 May 2;629(8010):235–243.

Ciliopathy patient variants reveal organelle-specific functions for TUBB4B in axonemal microtubules. Dodd DO, Mechaussier S et al. Science. 2024 Apr 26;384(6694):eadf5489.

Necroptosis blockade prevents lung injury in severe influenza. Gautam A, Boyd DF et al. Nature. 2024 Apr 25;628(8009):835–843.

Cryogenic electron tomography reveals novel structures in the apical complex of Plasmodium falciparum. Sun SY, Segev-Zarko L-a et al. mBio. 2024 Apr 10;15(4):e0286423.

Conformational ensemble of yeast ATP synthase at low pH reveals unique intermediates and plasticity in F1-Fo coupling. Sharma S, Luo M et al. Nat Struct Mol Biol. 2024 Apr;31(4):657-666.

Parental histone transfer caught at the replication fork. Li N, Gao Y et al. Nature. 2024 Mar 28;627(8005):890–897.

Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants. Hayes TK, Aquilanti E et al. Nat Commun. 2024 Mar 28;15(1):2742.

Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export. Ying W, Wang Y et al. Science. 2024 Mar 22;383(6689):eadj4591.

Flexibility of binding site is essential to the Ca(2+) selectivity in EF-hand calcium-binding proteins. Lai R, Li G, Cui Q. J Am Chem Soc. 2024 Mar 20;146(11):7628-7639.

Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements. Finci LI, Chakrabarti M et al. Commun Biol. 2024 Mar 2;7(1):260.

Activation of human STING by a molecular glue-like compound. Li J, Canham SM et al. Nat Chem Biol. 2024 Mar;20(3):365-372.

A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens. Mattson NM, Chan AKN et al. Nat Struct Mol Biol. 2024 Mar;31(3):465-475.

Native architecture of a human GBP1 defense complex for cell-autonomous immunity to infection. Zhu S, Bradfield CJ et al. Science. 2024 Mar 1;383(6686):eabm9903.

A new family of bacterial ribosome hibernation factors. Helena-Bueno K, Rybak MY et al. Nature. 2024 Feb 29;626(8001):1125–1132.

Transition of human γ-tubulin ring complex into a closed conformation during microtubule nucleation. Brito C, Serna M et al. Science. 2024 Feb 23;383(6685):870-876.

SlyB encapsulates outer membrane proteins in stress-induced lipid nanodomains. Janssens A, Nguyen VS et al. Nature. 2024 Feb 15;626(7999):617–625.

DockOpt: A tool for automatic optimization of docking models. Knight IS, Mailhot O et al. J Chem Inf Model. 2024 Feb 12;64(3):1004-1016.

Characterization and heterologous reconstitution of Taxus biosynthetic enzymes leading to baccatin III. Jiang B, Gao L et al. Science. 2024 Feb 9;383(6683):622-629.

Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127. Montoya S, Bourcier J et al. Science. 2024 Feb 2;383(6682):eadi5798.

Enhancer-driven 3D chromatin domain folding modulates transcription in human mammary tumor cells. Kocanova S, Raynal F et al. Life Sci Alliance. 2024 Feb;7(2):e202302154.

Cryo- EM structure of the mycobacterial 70S ribosome in complex with ribosome hibernation promotion factor RafH. Kumar N, Sharma S, Kaushal PS. Nat Commun. 2024 Jan 20;15(1):638.

A new antibiotic traps lipopolysaccharide in its intermembrane transporter. Pahil KS, Gilman MSA et al. Nature. 2024 Jan 18;625(7995):572–577.

From structural polymorphism to structural metamorphosis of the coat protein of flexuous filamentous potato virus Y. Kavčič L, Kežar A et al. Commun Chem. 2024 Jan 17;7(1):14.

Observation of a single protein by ultrafast X-ray diffraction. Ekeberg T, Assalauova D et al. Light Sci Appl. 2024 Jan 12;13(1):15.

Multilayer DNA origami with terminal interfaces that are flat and wide-area. Kilwing L, Lill P et al. ACS Nano. 2024 Jan 9;18(1):885-893.

Two-step covalent docking with attracting cavities. Goullieux M, Zoete V, Röhrig UF. J Chem Inf Model. 2023 Dec 25;63(24):7847-7859.

Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2. Zhu H, Tonelli F et al. Science. 2023 Dec 22;382(6677):1404-1411.

Structural insights into intron catalysis and dynamics during splicing. Xu L, Liu T et al. Nature. 2023 Dec 21;624(7992):682-688.

Structural and functional analyses of viral H2 protein of the vaccinia virus entry fusion complex. Kao C-F, Liu C-Y et al. J Virol. 2023 Dec 21;97(12):e0134323.

FOXP3 recognizes microsatellites and bridges DNA through multimerization. Zhang W, Leng F et al. Nature. 2023 Dec 14;624(7991):433–441.

Sialoglycan binding triggers spike opening in a human coronavirus. Pronker MF, Creutznacher R et al. Nature. 2023 Dec 7;624(7990):201–206.

Regulation of the cell division hydrolase RipC by the FtsEX system in Mycobacterium tuberculosis. Li J, Xu X et al. Nat Commun. 2023 Dec 4;14(1):7999.

Ribosomal stalk-captured CARF-RelE ribonuclease inhibits translation following CRISPR signaling. Mogila I, Tamulaitiene G et al. Science. 2023 Dec 1;382(6674):1036-1041.

Cryo-EM of Aβ fibrils from mouse models find tg-APPArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease. Zielinski M, Peralta Reyes FS et al. Nat Neurosci. 2023 Dec;26(12):2073-2080.

Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor. Noddings CM, Johnson JL, Agard DA. Nat Struct Mol Biol. 2023 Dec;30(12):1867-1877.

Mechanisms of neurotransmitter transport and drug inhibition in human VMAT2. Pidathala S, Liao S et al. Nature. 2023 Nov 30;623(7989):1086-1092.

Mechanism of target site selection by type V-K CRISPR-associated transposases. George JT, Acree C et al. Science. 2023 Nov 17;382(6672):eadj8543.

A practical guide to machine-learning scoring for structure-based virtual screening. Tran-Nguyen VK, Junaid M et al. Nat Protoc. 2023 Nov;18(11):3460-3511.

Structure and activation mechanism of the rice Salt Overly Sensitive 1 (SOS1) Na+/H+ antiporter. Zhang XY, Tang LH et al. Nat Plants. 2023 Nov;9(11):1924-1936.

Molecular orbital and topological electron density study of n → π* interactions: amides and thioamides cases. Briceño-Vargas FM, Quesadas-Rojas M et al. RSC Adv. 2023 Oct 26;13(45):31321-31329.

Structures illustrate step-by-step mitochondrial transcription initiation. Goovaerts Q, Shen J et al. Nature. 2023 Oct 26:622(7984):872–879.

Molecular mechanism of de novo replication by the Ebola virus polymerase. Peng Q, Yuan B et al. Nature. 2023 Oct 19;622(7983):603–610.

Cryo-EM structures reveal native GABAA receptor assemblies and pharmacology. Sun C, Zhu H et al. Nature. 2023 Oct 5;622(7981):195–201.

Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome. Zhang Z, Shibata T et al. Nature. 2023 Oct 5;622(7981):188–194.

Structural basis of the allosteric inhibition of human ABCG2 by nanobodies. Irobalieva RN, Manolaridis I et al. J Mol Biol. 2023 Oct 1;435(19):168234.

Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Zhang D, Ivica J et al. Nature. 2023 Sep 28;621(7980):877–882.

Descriptor-driven de novo design algorithms for DOCK6 using RDKit. Duarte Ramos Matos G, Pak S, Rizzo RC. J Chem Inf Model. 2023 Sep 25;63(18):5803-5822.

Structural basis for inactivation of PRC2 by G-quadruplex RNA. Song J, Gooding AR et al. Science. 2023 Sep 22;381(6664):1331-1337.

Neutralization, effector function and immune imprinting of Omicron variants. Addetia A, Piccoli L et al. Nature. 2023 Sep 21;621(7979):592–601.

Structural basis of mitochondrial protein import by the TIM23 complex. Sim SI, Chen Y et al. Nature. 2023 Sep 21;621(7979):620–626.

A pentameric TRPV3 channel with a dilated pore. Lansky S, Betancourt JM et al. Nature. 2023 Sep 7;621(7977):206–214.

DELE1 oligomerization promotes integrated stress response activation. Yang J, Baron KR et al. Nat Struct Mol Biol. 2023 Sep;30(9):1295-1302.

OPA1 helical structures give perspective to mitochondrial dysfunction. Nyenhuis SB, Wu X et al. Nature. 2023 Aug 31;620(7976):1109–1116.

Computation of absolute binding free energies for noncovalent inhibitors with SARS-CoV-2 main protease. Ghahremanpour MM, Saar A et al. J Chem Inf Model. 2023 Aug 28;63(16):5309-5318.

Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1. Liu CP, Yu Z et al. Science. 2023 Aug 25;381(6660):eadd8673.

Cryo-EM structure of the nucleocapsid-like assembly of respiratory syncytial virus. Wang Y, Zhang C et al. Signal Transduct Target Ther. 2023 Aug 22;8(1):323.

Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S. Guan H, Wang P et al. Nature. 2023 Aug 17;620(7974):669-675.

Structural basis for the binding of DNP and purine nucleotides onto UCP1. Kang Y, Chen L. Nature. 2023 Aug 3;620(7972):226–231.

Investigation of hydrated channels and proton pathways in a high-resolution cryo-EM structure of mammalian complex I. Grba DN, Chung I et al. Sci Adv. 2023 Aug 2;9(31):eadi1359.

Electrostatic ratchet for successive peptide synthesis in nonribosomal molecular machine RimK. Ohnuki J, Arimura Y et al. J Am Chem Soc. 2023 Jul 26;145(29):15963-15970.

Structures of 9-1-1 DNA checkpoint clamp loading at gaps from start to finish and ramification on biology. Zheng F, Georgescu RE et al. Cell Rep. 2023 Jul 25;42(7):112694.

Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants. Li M, Oliveira Passos D et al. Sci Adv. 2023 Jul 21;9(29):eadg5953.

Profound structural conservation of chemically cross-linked HIV-1 envelope glycoprotein experimental vaccine antigens. Martin GM, Russell RA et al. NPJ Vaccines. 2023 Jul 13;8(1):101.

Histone modifications regulate pioneer transcription factor cooperativity. Sinha KK, Bilokapic S et al. Nature. 2023 Jul 13;619(7969):378–384.

Organic-inorganic covalent-ionic molecules for elastic ceramic plastic. Fang W, Mu Z et al. Nature. 2023 Jul 13;619(7969):293–299.

Residue-level error detection in cryoelectron microscopy models. Reggiano G, Lugmayr W et al. Structure. 2023 Jul 6;31(7):860-869.e4.

A multi-enzyme machine polymerizes the Haemophilus influenzae type b capsule. Cifuente JO, Schulze J et al. Nat Chem Biol. 2023 Jul;19(7):865-877.

Structural basis for FGF hormone signalling. Chen L, Fu L et al. Nature. 2023 Jun 22;618(7966):862–870.

Outer membrane utilisomes mediate glycan uptake in gut Bacteroidetes. White JBR, Silale A et al. Nature. 2023 Jun 15;618(7965):583–589.

Structural model for factor X inhibition of IgM and complement-mediated neutralization of adenovirus. Wagner N, Shayakhmetov DM, Stewart PL. Viruses. 2023 Jun 9;15(6):1343.

Nuclear export of pre-60S particles through the nuclear pore complex. Li Z, Chen S et al. Nature. 2023 Jun 8;618(7964):411–418.

Structural basis of amine odorant perception by a mammal olfactory receptor. Guo L, Cheng J et al. Nature. 2023 Jun 1;618(7963):193–200.

Ligand and G-protein selectivity in the κ-opioid receptor. Han J, Zhang J et al. Nature. 2023 May 11;617(7960):417-425.

Redox potentials of uranyl ions in macrocyclic complexes: Quantifying the role of counter-ions. Sundararajan M. ACS Omega. 2023 May 10;8(20):18041-18046.

MELD-Bracket ranks binding affinities of diverse sets of ligands. Parui S, Robertson JC et al. J Chem Inf Model. 2023 May 8;63(9):2857-2865.

Molecular basis of translation termination at noncanonical stop codons in human mitochondria. Saurer M, Leibundgut M et al. Science. 2023 May 5;380(6644):531-536.

Structural basis of BAM-mediated outer membrane β-barrel protein assembly. Shen C, Chang S et al. Nature. 2023 May 4;617(7959):85–193.

Lesion recognition by XPC, TFIIH and XPA in DNA excision repair. Kim J, Li CL et al. Nature. 2023 May 4;617(7959):170–175.

A structural basis for prion strain diversity. Manka SW, Wenborn A et al. Nat Chem Biol. 2023 May;19(5):607-613.

Csx28 is a membrane pore that enhances CRISPR-Cas13b-dependent antiphage defense. VanderWal AR, Park JU et al. Science. 2023 Apr 28;380(6643):410-415.

Structural basis for GSDMB pore formation and its targeting by IpaH7.8. Wang C, Shivcharan S et al. Nature. 2023 Apr 20;616(7957):590–597.

Structural basis of sensory receptor evolution in octopus. Allard CAH, Kang G et al. Nature. 2023 Apr 13;616(7956):373-377.

Germline-encoded amino acid-binding motifs drive immunodominant public antibody responses. Shrock EL, Timms RT et al. Science. 2023 Apr 7;380(6640):eadc9498.

Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Mao C, Xiao P et al. Science. 2023 Apr 7;380(6640):eadd6220.

Structural and mechanistic insights into fungal β-1,3-glucan synthase FKS1. Hu X, Yang P et al. Nature. 2023 Apr 6;616(7955):190–198.

Norovirus MLKL-like protein initiates cell death to induce viral egress. Wang G, Zhang D et al. Nature. 2023 Apr 6;616(7955):152–158.

A sequence-based foldability score combined with AlphaFold2 predictions to disentangle the protein order/disorder continuum. Bruley A, Bitard-Feildel T et al. Proteins. 2023 Apr;91(4):466-484.

Integrative structural analysis of the type III secretion system needle complex from Shigella flexneri. Flacht L, Lunelli M et al. Protein Sci. 2023 Apr;32(4):e4595.

Immunoglobulin M perception by FcμR. Li Y, Shen H et al. Nature. 2023 Mar 30;615(7954):907–912.

Cysteine carboxyethylation generates neoantigens to induce HLA-restricted autoimmunity. Zhai Y, Chen L et al. Science. 2023 Mar 17;379(6637):eabg2482.

Structure of the human DICER-pre-miRNA complex in a dicing state. Lee YY, Lee H et al. Nature. 2023 Mar 9;615(7951):331–338.

Structure and function of Plasmodium actin II in the parasite mosquito stages. Lopez AJ, Andreadaki M et al. PLoS Pathog. 2023 Mar 6;19(3):e1011174.

Variable microtubule architecture in the malaria parasite. Ferreira JL, Pražák V et al. Nat Commun. 2023 Mar 3;14(1):1216.


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