The molecular architecture of the Dam1 kinetochore complex is defined by cross-linking based structural modelling. Zelter A, Bonomi M et al. Nat Commun. 2015 Nov 12;6:8673.
Activating mutations affecting the Dbl homology domain of SOS2 cause Noonan syndrome. Cordeddu V, Yin JC et al. Hum Mutat. 2015 Nov;36(11):1080-7.
Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions. Jiang J, Chan H et al. Science. 2015 Oct 30;350(6260):aab4070.
Evolution of an archaeal virus nucleocapsid protein from the
CRISPR-associated Cas4 nuclease.
Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization. Zhang L, Chen S et al. Science. 2015 Oct 23;350(6259):404-9.(Previously featured citations...)
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July 23, 2015
Chimera production release 1.10.2 is now available. Fixes include code signing for Mac OS X installation. The 1.10 series will be the last to support OS X 10.6 and 10.7. See the release notes for details.
January 9, 2015
Chimera production release 1.10.1 is now available. 64-bit builds are recommended for all capable platforms, and the 1.10 series will be the last to support OS X 10.6 and 10.7. See the release notes for details.
November 5, 2014
Chimera production release 1.10 is now available. 64-bit builds are recommended for all capable platforms, and v1.10 will be the last to support OS X 10.6 and 10.7. See the release notes for what's new.(Previous news...)
UCSF Chimera is a highly extensible program for interactive visualization and analysis of molecular structures and related data, including density maps, supramolecular assemblies, sequence alignments, docking results, trajectories, and conformational ensembles. High-quality images and animations can be generated. Chimera includes complete documentation and several tutorials, and can be downloaded free of charge for academic, government, non-profit, and personal use. Chimera is developed by the Resource for Biocomputing, Visualization, and Informatics, funded by the National Institutes of Health (NIGMS P41-GM103311).
The PDB/UniProt Info tool retrieves sequence and structure annotations for Protein Data Bank (PDB) entries using a Web service provided by the RCSB PDB. Sequences are displayed in Multalign Viewer, and feature annotations from UniProt are mapped onto the sequences as regions or colored boxes. In the region browser (figure at right):
Mutations that inactivate the tumor suppressor p53 are found in over 50% of human cancers, and most of the cancer-associated mutations are within its DNA-binding domain. The image shows a tetramer of the p53 DNA-binding domain complexed with DNA (Protein Data Bank entry 2ac0). The tetramer subunits are shown as light blue, green, orange, and yellow ribbons, with red spheres marking several major "hot spots" of mutation. The DNA is shown in purple and blue. (More samples...)