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Recent Citations

Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing. Puchades C, Rampello AJ et al. Science. 2017 Nov 3;358(6363). pii: eaao0464.

Design of coiled-coil protein-origami cages that self-assemble in vitro and in vivo. Ljubetič A, Lapenta F et al. Nat Biotechnol. 2017 Nov;35(11):1094-1101.

Solvatochromism and preferential solvation of Brooker's merocyanine in water-methanol mixtures. Tanaka Y, Kawashima Y et al. J Comput Chem. 2017 Oct 30;38(28):2411-2419.

CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing. Li X, Liu S et al. Nat Commun. 2017 Oct 19;8(1):1035.

Capsids and genomes of jumbo-sized bacteriophages reveal the evolutionary reach of the HK97 fold. Hua J, Huet A et al. MBio. 2017 Oct 17;8(5). pii: e01579-17.

(Previously featured citations...)

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News

October 24, 2017

Chimera production release 1.12 is now available (64-bit builds for Windows, Mac, and Linux). See the release notes for details.

September 12, 2017

A production release candidate (version 1.12) is available; please try it and report any problems. See the release notes for what's new.

March 13, 2017

For a nice 3D-printing protocol that uses Chimera, see 3D Printing of Biomolecular Models for Research and Pedagogy by Da Veiga Beltrame, Tyrwhitt-Drake, et al. today in JoVE!

(Previous news...)

Upcoming Events

UCSF Chimera is a highly extensible program for interactive visualization and analysis of molecular structures and related data, including density maps, supramolecular assemblies, sequence alignments, docking results, trajectories, and conformational ensembles. High-quality images and animations can be generated. Chimera includes complete documentation and several tutorials, and can be downloaded free of charge for academic, government, nonprofit, and personal use. Chimera is developed by the Resource for Biocomputing, Visualization, and Informatics (RBVI), funded by the National Institutes of Health (NIGMS P41-GM103311).

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the RBVI, following UCSF Chimera.

Feature Highlight

phosphomannomutase morphing animation

Morphing

Different conformations and even different proteins can be compared by morphing from one structure to another. Users can specify the method of coordinate interpolation and how many intermediate structures should be generated. The result is displayed in Chimera's trajectory viewer, MD Movie. The morph can then be saved in coordinate form or recorded as an animation.

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Gallery Sample

p53 Cancer Mutations

Mutations that inactivate the tumor suppressor p53 are found in over 50% of human cancers, and most of the cancer-associated mutations are within its DNA-binding domain. The image shows a tetramer of the p53 DNA-binding domain complexed with DNA (Protein Data Bank entry 2ac0). The tetramer subunits are shown as light blue, green, orange, and yellow ribbons, with red spheres marking several major "hot spots" of mutation. The DNA is shown in purple and blue. (More samples...)