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Recent Citations

Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase. Verba KA, Wang RY et al. Science. 2016 Jun 24;352(6293):1542-7.

Diverse roles of assembly factors revealed by structures of late nuclear pre-60S ribosomes. Wu S, Tutuncuoglu B et al. Nature. 2016 Jun 2;534(7605):133-7.

Using cryo-EM to map small ligands on dynamic metabolic enzymes: studies with glutamate dehydrogenase. Borgnia MJ, Banerjee S et al. Mol Pharmacol. 2016 Jun;89(6):645-51.

Structure of the intact ATM/Tel1 kinase. Wang X, Chu H et al. Nat Commun. 2016 May 27;7:11655.

Near-atomic resolution visualization of human transcription promoter opening. He Y, Yan C et al. Nature. 2016 May 19;533(7603):359-65.

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Chimera Search

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News

June 23, 2016

PLOS Computational Biology announces winning T-shirt design created by Luigi Di Costanzo (RCSB Protein Data Bank) using UCSF Chimera.

April 6, 2016

A production release candidate (v1.11) is available; please try it and report any problems. 64-bit builds are now recommended for all capable platforms, and v1.11 will be the last to support 32-bit builds. See the release notes for what's new.

July 23, 2015

Chimera production release 1.10.2 is now available. Fixes include code signing for Mac OS X installation. The 1.10 series will be the last to support OS X 10.6 and 10.7. See the release notes for details.

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Upcoming Events

UCSF Chimera is a highly extensible program for interactive visualization and analysis of molecular structures and related data, including density maps, supramolecular assemblies, sequence alignments, docking results, trajectories, and conformational ensembles. High-quality images and animations can be generated. Chimera includes complete documentation and several tutorials, and can be downloaded free of charge for academic, government, non-profit, and personal use. Chimera is developed by the Resource for Biocomputing, Visualization, and Informatics (RBVI), funded by the National Institutes of Health (NIGMS P41-GM103311).

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the RBVI, following UCSF Chimera. It is in early development and not yet publicly released, with release anticipated sometime in 2016.

Feature Highlight

DNA and netropsin

Molecular Graphics

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Gallery Sample

Sliced Potassium Channel

Potassium channel (Protein Data Bank entry 1bl8) on a dark slate blue background with potassium ions shown in firebrick. The channel is comprised of four chains. Each chain has been rainbow-colored from blue at the N-terminus to red at the C-terminus, but only the surface of the channel is shown. The surface has been sliced with a per-model clipping plane. The surface cap color is plum except with opacity set to 0.8. The shininess and brightness have been set to 128 and 8, respectively, and the lights on the scene have been moved from their default positions. The subdivision quality (related to the smoothness of the spherical ions) is 5.0, and the molecular surface was computed with probe radius and vertex density set to 1.0 and 6.0, respectively. (More samples...)