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Recent Citations

A molecular ruler determines the repeat length in eukaryotic cilia and flagella. Oda T, Yanagisawa H et al. Science. 2014 Nov 14;346(6211):857-60.

Drug sensing by the ribosome induces translational arrest via active site perturbation. Arenz S, Meydan S et al. Mol Cell. 2014 Nov 6;56(3):446-52.

Allosteric signalling in the outer membrane translocation domain of PapC usher. Farabella I, Pham T et al. eLife. 2014 Oct 28;3.

Molecular basis for the ribosome functioning as an L-tryptophan sensor. Bischoff L, Berninghausen O, Beckmann R. Cell Rep. 2014 Oct 23;9(2):469-75.

Structural mechanism of glutamate receptor activation and desensitization. Meyerson JR, Kumar J et al. Nature. 2014 Oct 16;514(7522):328-34.

(Previously featured citations...)

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News

November 5, 2014

Chimera production release 1.10 is now available. 64-bit builds are recommended for all capable platforms, and v1.10 will be the last to support OS X 10.6 and 10.7. See the release notes for what's new.

October 23, 2014

A production release candidate (v1.10) is available; please try it and report any problems. 64-bit builds are now recommended for all capable platforms, and v1.10 will be the last to support OS X 10.6 and 10.7. See the release notes for what's new.

August 15, 2014

We are delighted to announce the publication of a new book, Computational and Visualization Techniques for Structural Bioinformatics Using Chimera, written by Forbes J. Burkowski (University of Waterloo).

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Upcoming Events

UCSF Chimera is a highly extensible program for interactive visualization and analysis of molecular structures and related data, including density maps, supramolecular assemblies, sequence alignments, docking results, trajectories, and conformational ensembles. High-quality images and animations can be generated. Chimera includes complete documentation and several tutorials, and can be downloaded free of charge for academic, government, non-profit, and personal use. Chimera is developed by the Resource for Biocomputing, Visualization, and Informatics, funded by the National Institutes of Health (NIGMS P41-GM103311).

Feature Highlight

Multiscale Models

Multiscale Models

The Multiscale Models extension allows Chimera to display large complexes such as virus capsids, ribosomes, and chromatin. It displays the quaternary structure of PDB models and allows subunits to be selected and shown in atomic detail. Matrices are read from PDB files that specify the biological unit. Crystallographic packing can also be shown.

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Gallery Sample

p53 Cancer Mutations

Mutations that inactivate the tumor suppressor p53 are found in over 50% of human cancers, and most of the cancer-associated mutations are within its DNA-binding domain. The image shows a tetramer of the p53 DNA-binding domain complexed with DNA (Protein Data Bank entry 2ac0). The tetramer subunits are shown as light blue, green, orange, and yellow ribbons, with red spheres marking several major "hot spots" of mutation. The DNA is shown in purple and blue. (More samples...)