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Sialoglycan binding triggers spike opening in a human coronavirus. Pronker MF, Creutznacher R et al. Nature. 2023 Dec 7;624(7990):201–206.

Ribosomal stalk-captured CARF-RelE ribonuclease inhibits translation following CRISPR signaling. Mogila I, Tamulaitiene G et al. Science. 2023 Dec 1;382(6674):1036-1041.

Cryo-EM of Aβ fibrils from mouse models find tg-APPArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease. Zielinski M, Peralta Reyes FS et al. Nat Neurosci. 2023 Dec;26(12):2073-2080.

Mechanisms of neurotransmitter transport and drug inhibition in human VMAT2. Pidathala S, Liao S et al. Nature. 2023 Nov 30;623(7989):1086-1092.

Mechanism of target site selection by type V-K CRISPR-associated transposases. George JT, Acree C et al. Science. 2023 Nov 17;382(6672):eadj8543.

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October 30-31, 2023

Planned downtime: The Chimera and ChimeraX websites and associated web services will be unavailable Oct 30 8am PDT – Oct 31 11:59pm PDT.

April 19, 2023

Chimera production release 1.17.1 is now available, fixing an issue with 1.17 for Windows and Linux. See the release notes for details.

April 13, 2023

Chimera production release 1.17 is now available. Updating is required to keep using the tools that run Blast Protein, Modeller, and multiple sequence alignment with Clustal Omega or MUSCLE, as these will soon stop working in older versions. See the release notes for details.

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Please note that UCSF Chimera is legacy software that is no longer being developed or supported. Users are strongly encouraged to try UCSF ChimeraX, which is under active development.

UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.

We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features in addition to nearly all the capabilities of Chimera (details...).

Chimera is no longer under active development. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.

Feature Highlight

1le4 sequence

Annotations from UniProt

The PDB/UniProt Info tool retrieves sequence and structure annotations for Protein Data Bank (PDB) entries using a Web service provided by the RCSB PDB. Sequences are displayed in Multalign Viewer, and feature annotations from UniProt are mapped onto the sequences as regions or colored boxes. In the region browser (figure at right):

  • making a region Active selects any corresponding structure residues for further operations; only one region can be active at a time
  • making a region Shown displays it in the sequence window
  • the square color wells show (and allow changing) the region interior and border colors
UniProt annotations can also be fetched along with a sequence or mapped to a sequence already in Multalign Viewer regardless of whether the sequence is associated with a structure.

(More features...)

Gallery Sample

Peroxiredoxin Wreath

Peroxiredoxins are enzymes that help cells cope with stressors such as high levels of reactive oxygen species. The image shows a decameric peroxiredoxin from human red blood cells (Protein Data Bank entry 1qmv), styled as a holiday wreath.

See also the RBVI holiday card gallery.

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