Genetic landscape of esophageal squamous cell carcinoma. Gao YB, Chen ZL et al. Nat Genet. 2014 Oct;46(10):1097-102.
A broad HIV-1 inhibitor blocks envelope glycoprotein transitions critical for entry. Herschhorn A, Gu C et al. Nat Chem Biol. 2014 Oct;10(10):845-52.
A guide to the visual analysis and communication of biomolecular structural data. Johnson GT, Hertig S. Nat Rev Mol Cell Biol. 2014 Oct;15(10):690-8.
Crystal structure of the CRISPR RNA-guided surveillance complex from Escherichia coli. Jackson RN, Golden SM et al. Science. 2014 Sep 19;345(6203):1473-9.
Molecular architecture and mechanism of the anaphase-promoting complex. Chang L, Zhang Z et al. Nature. 2014 Sep 18;513(7518):388-93.(Previously featured citations...)
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October 23, 2014
A production release candidate (v1.10) is available; please try it and report any problems. 64-bit builds are now recommended for all capable platforms, and v1.10 will be the last to support OS X 10.6 and 10.7. See the release notes for what's new.
August 15, 2014
We are delighted to announce the publication of a new book, Computational and Visualization Techniques for Structural Bioinformatics Using Chimera, written by Forbes J. Burkowski (University of Waterloo).
May 13, 2014(Previous news...)
UCSF Chimera is a highly extensible program for interactive visualization and analysis of molecular structures and related data, including density maps, supramolecular assemblies, sequence alignments, docking results, trajectories, and conformational ensembles. High-quality images and animations can be generated. Chimera includes complete documentation and several tutorials, and can be downloaded free of charge for academic, government, non-profit, and personal use. Chimera is developed by the Resource for Biocomputing, Visualization, and Informatics, funded by the National Institutes of Health (NIGMS P41-GM103311).
Different conformations and even different proteins can be compared by morphing from one structure to another. Users can specify the method of coordinate interpolation and how many intermediate structures should be generated. The result is displayed in Chimera's trajectory viewer, MD Movie. The morph can then be saved in coordinate form or recorded as an animation.(More features...)
BILD format was used in Chimera to annotate the barrel structure of green fluorescent protein with its centroid, major axis (red arrow), and an enclosing cylinder (shown with green hoops). The BILD file green.bild was generated with the python program green.py using the coordinates in green.pdb. Gallery entry courtesy of Mike Ess, Yeast Resource Center, University of Washington. (More samples...)