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Recent Citations

Crystal structure of human herpesvirus 6B tegument protein U14. Wang B, Nishimura M et al. PLoS Pathog. 2016 May 6;12(5):e1005594.

Femtosecond structural dynamics drives the trans/cis isomerization in photoactive yellow protein. Pande K, Hutchison CD et al. Science. 2016 May 6;352(6286):725-9.

Cholesteryl ester transfer between lipoproteins does not require a ternary tunnel complex with CETP. Lauer ME, Graff-Meyer A et al. J Struct Biol. 2016 May;194(2):191-8.

Mapping and modeling of a strain-specific epitope in the Norwalk virus capsid inner shell. Parra GI, Sosnovtsev SV et al. Virology. 2016 May;492:232-41.

Structure and organization of heteromeric AMPA-type glutamate receptors. Herguedas B, García-Nafría J et al. Science. 2016 Apr 29;352(6285):aad3873.

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Chimera Search

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April 6, 2016

A production release candidate (v1.11) is available; please try it and report any problems. 64-bit builds are now recommended for all capable platforms, and v1.11 will be the last to support 32-bit builds. See the release notes for what's new.

July 23, 2015

Chimera production release 1.10.2 is now available. Fixes include code signing for Mac OS X installation. The 1.10 series will be the last to support OS X 10.6 and 10.7. See the release notes for details.

January 9, 2015

Chimera production release 1.10.1 is now available. 64-bit builds are recommended for all capable platforms, and the 1.10 series will be the last to support OS X 10.6 and 10.7. See the release notes for details.

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Upcoming Events

UCSF Chimera is a highly extensible program for interactive visualization and analysis of molecular structures and related data, including density maps, supramolecular assemblies, sequence alignments, docking results, trajectories, and conformational ensembles. High-quality images and animations can be generated. Chimera includes complete documentation and several tutorials, and can be downloaded free of charge for academic, government, non-profit, and personal use. Chimera is developed by the Resource for Biocomputing, Visualization, and Informatics (RBVI), funded by the National Institutes of Health (NIGMS P41-GM103311).

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the RBVI, following UCSF Chimera. It is in early development and not yet publicly released, with release anticipated sometime in 2016.

Feature Highlight

density display

Density Display

Electron density maps can be read from local files or fetched from databases. Chimera's Volume Viewer allows adjusting contour levels interactively, showing multiple isosurfaces for a given map, and restricting display to a zone around selected atoms. The figure shows PDB entry 2fma and its electron density map. Settings are similar to those described in the Density Display tutorial. See also: Chimera volume display guide

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Gallery Sample

Orexin Receptor Complex

The image shows the structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant, Protein Data Bank entry 4s0v. The drug is shown as spheres colored by element, and the receptor as ribbons with secondary structure elements rainbow-colored from blue at the N-terminus to red at the C-terminus. (More samples...)