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Recent Citations

Structure of the yeast spliceosomal postcatalytic P complex. Liu S, Li X et al. Science. 2017 Dec 8;358(6368):1278-1283.

Structural insight into the rearrangement of the switch I region in GTP-bound G12A K-Ras. Xu S, Long BN et al. Acta Crystallogr D Struct Biol. 2017 Dec 1;73(Pt 12):970-984.

3.9 Å structure of the yeast Mec1-Ddc2 complex, a homolog of human ATR-ATRIP. Wang X, Ran T et al. Science. 2017 Dec 1;358(6367):1206-1209.

Structural basis for the initiation of eukaryotic transcription-coupled DNA repair. Xu J, Lahiri I et al. Nature. 2017 Nov 30;551(7682):653-657.

Primer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S cluster. Holzer S, Yan J et al. Nat Commun. 2017 Nov 23;8(1):1718.

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Chimera Search

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October 24, 2017

Chimera production release 1.12 is now available (64-bit builds for Windows, Mac, and Linux). See the release notes for details.

September 12, 2017

A production release candidate (version 1.12) is available; please try it and report any problems. See the release notes for what's new.

March 13, 2017

For a nice 3D-printing protocol that uses Chimera, see 3D Printing of Biomolecular Models for Research and Pedagogy by Da Veiga Beltrame, Tyrwhitt-Drake, et al. today in JoVE!

(Previous news...)

Upcoming Events

UCSF Chimera is a highly extensible program for interactive visualization and analysis of molecular structures and related data, including density maps, supramolecular assemblies, sequence alignments, docking results, trajectories, and conformational ensembles. High-quality images and animations can be generated. Chimera includes complete documentation and several tutorials, and can be downloaded free of charge for academic, government, nonprofit, and personal use. Chimera is developed by the Resource for Biocomputing, Visualization, and Informatics (RBVI), funded by the National Institutes of Health (NIGMS P41-GM103311).

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the RBVI, following UCSF Chimera.

Feature Highlight

Consurf coloring and alignment

Showing ConSurf Results

The ConSurf Server provides results as Chimera Web data; after browser configuration, a single click displays the color-coded query structure and multiple sequence alignment with phylogenetic tree and custom headers in a locally installed copy of Chimera (details).

Special thanks to Elana Erez and the Ben-Tal and Pupko groups at Tel Aviv University, and to Fabian Glaser at the Technion.

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Gallery Sample

G Protein Interface Surface

Heterotrimeric G protein (Protein Data Bank entry 1gg2) with the alpha subunit shown in green, the beta subunit in light blue, and the gamma subunit in brown. The Intersurf tool was used to show the interface between the alpha and beta subunits. The interface surface is colored to show the distance between atoms across the interface (red for closer together, blue for farther apart). (More samples...)