Changes between Version 46 and Version 47 of NTTData

Timestamp:

Aug 12, 2021, 5:27:52 PM (4 years ago)

Author:

Tom Goddard

Comment:

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NTTData

@@ -321 +321 @@
 Phil is interested in the use to fill in missing segments of experimental structures. !AlphaFold was easier to use than other methods he tried and gave a reasonable conformation (based on other data) as the top hit.
 
-Tony mentions ongoing tests using !AlphaFold for building complexes, and something about putting U in the sequence to link multiple proteins (?) He also suggests an option to trim away lower-confidence residues.  Currently can be done with bfactor attribute specification.
+Tony mentions ongoing tests using !AlphaFold for building complexes, and a trick of putting U characters in the sequence to make linkers for a fusion protein. He also suggests an option to hide lower-confidence residues.  Currently can be done with bfactor attribute specification.
 
 Phil: a cautionary tale is progesterone receptor 1a28 alphafold match, you can see that multiple domains even within a monomer chain are not placed as expected relative to each other.