Changes between Version 43 and Version 44 of NTTData


Ignore:
Timestamp:
Aug 12, 2021, 2:04:35 PM (4 years ago)
Author:
Elaine Meng
Comment:

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  • NTTData

    v43 v44  
    319319Lately all the attention is on !AlphaFold. TG described "alphafold match" and showed the 3p5b and 6vpv examples. Plans are to add "alphafold search" for when you don't have a structure, and blast search as alternative to current blat, and maybe eventually a service for running predictions. Also demo'ed Google colab.
    320320
     321Phil is interested in the use to fill in missing segments of experimental structures. AlphaFold was easier to use than other methods he tried and gave a reasonable conformation (based on other data) as the top hit.
     322
     323Tony mentions ongoing tests using !AlphaFold for building complexes, and something about putting U in the sequence to link multiple proteins (?)
     324
     325Phil: a cautionary tale is progesterone receptor 1a28 alphafold match, you can see that multiple domains even within a monomer chain are not placed as expected relative to each other.
     326