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Featured Citations

Quantum spin resonance in engineered proteins for multimodal sensing. Abrahams G, Štuhec A et al. Nature. 2026 Jan 29;649(8099):1172–1179.

RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity. Dmytrenko O, Yuan B et al. Nature. 2026 Jan 29;649(8099):1312–1321.

Multiple protein structure alignment at scale with FoldMason. Gilchrist CLM, Mirdita M, Steinegger M. Science. 2026 Jan 29;391(6784):485-488.

An ATP-gated molecular switch orchestrates human mRNA export. Hohmann U, Graf M et al. Nature. 2026 Jan 22;649(8098):1042–1050.

ZAK activation at the collided ribosome. Huso VL, Niu S et al. Nature. 2026 Jan 22;649(8098):1051–1060.

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News

December 25, 2025

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The RBVI wishes you a safe and happy holiday season! See our 2025 card and the gallery of previous cards back to 1985.

December 16, 2025

The ChimeraX 1.11 production release is available! See the change log for what's new.

November 21, 2025

The ChimeraX 1.11 release candidate is available – please try it and report any issues. See the change log for what's new. This will be the last release to support Red Hat Enterprise Linux 8 and its derivatives.

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UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.

ChimeraX is developed with support from National Institutes of Health R01-GM129325.

Bluesky logo ChimeraX on Bluesky: @chimerax.ucsf.edu

Feature Highlight

2ptt interchain H-bonds screenshot

Interactive H-Bond Histogram

Hydrogen bonds (H-bonds) can be identified with the H-Bonds tool, hbonds command, or the Molecule Display icon computer generated image and plotted as an interactive histogram with the command crosslinks histogram.

The ChimeraX graphics window shows the complex between a natural killer cell receptor 2B4 and its ligand CD48 (PDB 2ptt). The receptor protein is blue, the ligand protein pink, and H-bonds between them dashed yellow, with H-bonding residues labeled. Although not done here, the H-bonds could also be labeled by distance.

The histogram of H-bond distances on the top right is interactive: when the cursor is placed over a bar in the histogram, the corresponding H-bonds are temporarily enlarged in the 3D view and the others hidden. For image setup other than orientation, see the command file hb3.cxc.

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Example Image

2015 holiday card with ribosome image

The Human Ribosome

The architecture of the human ribosome has been determined at near-atomic resolution by electron microscopy (Anger et al., Nature 497:80 (2013)). The structure, comprising 82 proteins and five RNA molecules, is shown with shadows cast from all directions to accentuate depth. In the background are schematic representations of contacts between the component molecules.

See the image setup script card.cxc using the 'Tis the Season color palette (credit to MrsP). See also the RBVI holiday card gallery.

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