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Delta-type glutamate receptors are ligand-gated ion channels. Wang H, Ahmed F et al. Nature. 2025 Nov 27;647(8091):1063–1071.
Structural basis of T-loop-independent recognition and activation of CDKs by the CDK-activating kinase. Cushing VI, McGeoch AJS et al. Science. 2025 Nov 27;390(6776):911-917.
Rapid compensatory evolution within a multiprotein complex preserves telomere integrity. Lin SY, Futeran HR et al. Science. 2025 Nov 27;390(6776):918-924.
Myeloperoxidase transforms chromatin into neutrophil extracellular traps. Burn GL, Raisch T et al. Nature. 2025 Nov 20;647(8090):747-756.
Sex and smoking bias in the selection of somatic mutations in human bladder. Calvet F, Blanco Martinez-Illescas R et al. Nature. 2025 Nov 13;647(8089):436-444.
More citations...News
November 21, 2025
The ChimeraX 1.11 release candidate is available – please try it and report any issues. See the change log for what's new. This will be the last release to support Red Hat Enterprise Linux 8 and its derivatives.
July 24, 2025
ChimeraX 1.10.1 is now available, fixing the problem in 1.10 of repeat registration requests to some users.
June 26, 2025
The ChimeraX 1.10 production release is available! See the change log for what's new.
Previous news...Upcoming Events
UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.
ChimeraX is developed with support from National Institutes of Health R01-GM129325.
Feature Highlight
Pockets and cavities in protein structures can be identified with the
Find Cavities
tool or
kvfinder command.
These run KVFinder, a method based on surface shape
developed by the Lopes-de-Oliveira group at the
Brazilian Biosciences National Laboratory
(details...).
As shown in the figure, the results are listed in an interactive
cavity
list and can be displayed as dot clouds and/or surfaces.
The latest iteration of this feature
is available in ChimeraX 1.10 daily builds 4/17/25 and newer.
For image setup other than position and the specific cavity colors
(which are assigned randomly after a calculation), see the command file
kvfinder.cxc.
Example Image
Atomic B-factor values are read from PDB and mmCIF input files
and assigned as attributes
that can be shown with
coloring
and used in
atom specification.
This example shows B-factor variation within a structure of the
HIV-1 protease bound to an inhibitor
(PDB 4hvp).
For complete image setup, including positioning,
color key, and label,
see the command file bfactor.cxc.
Additional color key examples can be found in tutorials:
Coloring by
Electrostatic Potential,
Coloring by Sequence Conservation
Find Cavities
B-factor Coloring
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