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Structure of mitochondrial pyruvate carrier and its inhibition mechanism. He Z, Zhang J et al. Nature. 2025 May 1;641(8061):250–257.
Structures and mechanism of the human mitochondrial pyruvate carrier. Liang J, Shi J et al. Nature. 2025 May 1;641(8061):258-265.
Metabolic signaling of ceramides through the FPR2 receptor inhibits adipocyte thermogenesis. Lin H, Ma C et al. Science. 2025 May 1;388(6746):eado4188.
Chanoclavine synthase operates by an NADPH-independent superoxide mechanism. Chen CC, Yu ZP et al. Nature. 2025 Apr 17;640(8059):840-846.
A small-molecule SARS-CoV-2 inhibitor targeting the membrane protein. Van Damme E, Abeywickrema P et al. Nature. 2025 Apr 10;640(8058):506–513.
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March 6, 2025
Chimera production release 1.19 is now available, fixing the ability to fetch structures from the PDB (details...).
December 25, 2024
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October 14, 2024
Planned downtime: The Chimera and ChimeraX websites, web services (Blast Protein, Modeller, ...) and cgl.ucsf.edu e-mail will be unavailable starting Monday, Oct 14 10 AM PDT, continuing throughout the week and potentially the weekend (Oct 14-20).
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UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.
We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features in addition to nearly all the capabilities of Chimera (details...).
Chimera is no longer under active development. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.
Feature Highlight
Volume data can be shown a single plane (or slab) at a time with the Planes feature in Volume Viewer. Plane display can be set to oscillate along the data X, Y, or Z axis, or the plane location can be specified interactively with a slider.
(More features...)Gallery Sample
Peroxiredoxins are enzymes that help cells cope with stressors such as high levels of reactive oxygen species. The image shows a decameric peroxiredoxin from human red blood cells (Protein Data Bank entry 1qmv), styled as a holiday wreath.
See also the RBVI holiday card gallery.
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