[[PageOutline]] = Ideas and discussions for the RBVI 2011 Site Visit = == Scenarios == === Scenario 1 === * SFLD/Cytoscape/Chimera === Scenario 2 === * Chimera/Volume Tools/Cytoscape(?) == Ideas of what to show == === TR&D 1 === === TR&D 2 === * Building a "composite model" and linking molecules, maps and sequences of components. * Chimera analysis web log. Would be cool to demo WebGL embedded in Chimera log then shown on a smart phone or tablet as a way to facilitate hallway/lecture-hall/lunch collaborative work. ==== Biological Systems ==== * [http://www.cgl.ucsf.edu/chimera/data/hiv-core-june2011/hivcore.html HIV Capsid] - Illustrates composite model building of HIV conical core particle. Capsid protein interfaces highly conserved drug target (June 2011 PNAS [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136285/?tool=pubmed paper]) * [http://www.cgl.ucsf.edu/chimera/animations/hivrna/hivrna.mov HIV RNA] - Secondary structure of full HIV RNA, I made 3-d model and animation with Chimera script. Nature 2009 [http://www.ncbi.nlm.nih.gov/pubmed/19661910 paper]). * [http://www.cgl.ucsf.edu/home/goddard/temp/dengue2.mov Dengue virus] - Maturation of dengue virus involves major rearchitecting of capsid. Chimera animation shows hypothetical model from Michael Rossmann lab. * [http://www.cgl.ucsf.edu/Research/auer/gut-sep2010/ Termite gut] - Segmentation tool demo. * Muscle filaments, myosin / actin / tropomyosin. Another good "composite" model example. Haven't done much with this system yet though. Recent Roger Craig / Raul Padron [http://www.ncbi.nlm.nih.gov/pubmed/21705660 paper], PNAS July 2011 === TR&D 3 === === TR&D 4 === * Incremental loading of networks * Fuzzy clusters * Invoking Cytoscape from Chimera * SFLDLoader2??