Changes between Version 18 and Version 19 of SiteVisit

Timestamp:

Sep 7, 2011, 2:31:50 PM (15 years ago)

Author:

goddard

Comment:

--

SiteVisit

@@ -45 +45 @@
 
  HIV Capsid
- * [http://www.cgl.ucsf.edu/chimera/data/hiv-core-june2011/hivcore.html HIV Capsid] - Illustrates composite model building of HIV conical core particle.  Capsid protein interfaces highly conserved drug target (June 2011 PNAS [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136285/?tool=pubmed paper])
+ * [http://www.cgl.ucsf.edu/chimera/data/hiv-core-june2011/hivcore.html HIV Capsid] - Illustrates composite model building of HIV conical core particle.
+  * Some capsid protein interfaces have few viable multisite mutations that enable drug resistance.  June 2011 PNAS [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136285/?tool=pubmed paper].  This article is quite theoretical but does compare results to HIV resistant patients' cyto-toxic lymphocite HLA epitopes that support their conclusions.
+  * New Approaches for Antiviral Targeting of HIV Assembly, JMB July 2011 review, [http://www.ncbi.nlm.nih.gov/pubmed/21762804 paper]. Describes several capsid assembly inhibitors or stablizers/destabilizers.  Only one (Bevirimat) reached clinical trials with only some patients responding favorably.  Article emphasizes escape mutant issues.
  * [http://plato.cgl.ucsf.edu/chimera/data/tutorials/eman2011 Rous sarcoma virus] - Retrovirus with very similar capsid to HIV.  Did EM fitting and comparison to HIV at EMAN 2011 workshop. 50 minute [http://plato.cgl.ucsf.edu/chimera/videodoc/RousSarcomaVirus/ video].
  * [http://www.cgl.ucsf.edu/chimera/animations/hivrna/hivrna.mov HIV RNA] - Secondary structure of full HIV RNA, I made 3-d model and animation with Chimera script. Nature 2009 [http://www.ncbi.nlm.nih.gov/pubmed/19661910 paper]).  Might add nucleocapsid protein tightly packed on RNA, and collapse RNA into capsid.