Changes between Version 3 and Version 4 of HIVspikes

Timestamp:

Sep 25, 2009, 11:56:30 AM (17 years ago)

Author:

goddard

Comment:

--

HIVspikes

@@ -26 +26 @@
 [[Image(800px-HIV_Virion-en-2.png)]]
 
+EM tomography view of HIV particles (Stephen Fuller lab).
+
+[[Image(fuller_siv.png)]]
+
+Will show some tomography data and how to get from A to B in above figure.
+
+There are about 15 gp120 crystal structures, all monomeric.  The 2 new bNAbs
+bind only to trimeric gp120 spikes, not to the monomeric form.  The trimer
+conformation can be found from the EM tomography data, averaging and fitting.
+
+
+
 {{{
 BLAST PDB for gp120, ~15 structures.