Changes between Version 10 and Version 11 of HIVspikes


Ignore:
Timestamp:
Sep 25, 2009, 4:42:17 PM (17 years ago)
Author:
goddard
Comment:

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  • HIVspikes

    v10 v11  
    130130those sequences.
    131131
    132 {{{
     132== SAXS ==
    133133
    134 SAXS profile of gp120 / FAB / CD4 complex.
     134SAXS profile of gp120 / FAB / CD4 complex could be used to compare conformational states.
     135Bound gp120 and CD4 was studied by SAXS in
     136
     137>Binding of full-length HIV-1 gp120 to CD4 induces structural reorientation around the gp120 core.[[BR]]
     138>Ashish, Garg R, Anguita J, Krueger JK.[[BR]]
     139>Biophys J. 2006 Sep 15;91(6):L69-71. [http://www.ncbi.nlm.nih.gov/pubmed/16844755 PubMed 16844755]
     140
     141We could show SAXS profile calculation of different conformations.  Would be best to get
     142experimental SAXS data.  Did not see any database with HIV SAXS on web.  Could just
     143make some example target conformation profile and demonstrate testing alternatives against it.
     144
     145[[Image(saxs.png)]]
     146
     147== Plastic trimer model ==
    135148
    136149Make plastic model of gp120 trimers in 5 parts with bound CD4 and FAB
    137 connected by magnets, pieces colored distinctly.
    138 
    139 }}}
     150connected by magnets, pieces colored distinctly.  Maybe include gp41 stalk.