Changes between Initial Version and Version 1 of HIVspikes

Timestamp:

Sep 25, 2009, 11:37:12 AM (17 years ago)

Author:

goddard

Comment:

--

HIVspikes

@@ +1 @@
+= HIV Spike Demo Storyboard =
+
+Storyboard for HIV spike demonstration for RBVI advisory committee meeting on November 13, 2009.
+
+== Aim of demonstration ==
+
+Aim is to show EM, sequence, and network visualization tools applied to a single biological problem.
+
+== Biological Problem ==
+
+The specific biological problem is to understand interactions of broadly neutralizing antibodies (bNAb)
+with HIV spike proteins gp120 and gp41.  The spikes recognize CD4 receptors on human T-cells to
+identify and infect those cells.  The motivation is to develop an HIV vaccine which works by
+eliciting production of these antibodies.  This month two new bNAbs were reported that are effective
+against more HIV strains and at lower antibody concentrations than the previously known half-dozen
+bNAbs.
+
+>Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target.[[BR]]
+>Walker LM, et al.[[BR]]
+>Science. 2009 Sep 3 [http://www.ncbi.nlm.nih.gov/pubmed/19729618 PubMed 19729618]
+
+
+