Core 1: Chimera Molecular Modeling System

Specific Aims

• Specific Aim 1: Develop web infrastructure, both server and Chimera client software, to facilitate access to data via the Internet. Products of this aim are addition RBVI web services, e.g., multiple sequence alignment, and Chimera interfaces to IMP (Sali DBP) and SFLD (Core 3).
• Specific Aim 2: Enhance Chimera-Cytoscape link to integrate molecular and network visualization. Products are Chimera functionality that start with molecular models and display (a) residue contacts as a network, (b) similarity networks to related sequences, and (c) context within pathway networks.
• Specific Aim 3: Enhance Chimera functionality. Products are more flexible sequence annotation methods, animation capabilities, and refactored code for better documentation and portability.
• Specific Aim 4: Design and develop a web-browser-based visualization and modeling analog to Chimera.