| | 1 | --------------------------------------------------------------------------- |
| | 2 | don't include papers... they will go in the Chimera Software Dev project |
| | 3 | --------------------------------------------------------------------------- |
| | 4 | "Chimera Outreach and Training" subproject for CGL annual report |
| | 5 | |
| | 6 | activities Jun 1, 2007 - May 31, 2008 |
| | 7 | --------------------------------------------------------------------------- |
| | 8 | |
| | 9 | May 16, 2007 |
| | 10 | Chimera training held at UCSF for Richard Newman who creates visualizations |
| | 11 | for the Electron Microscopy Data Bank run by the European Bioinformatics |
| | 12 | Institute. |
| | 13 | - Tom Goddard |
| | 14 | |
| | 15 | Jun 8, 2007 |
| | 16 | Chimera Release Party - Genentech Hall, UCSF (>100 attendees) |
| | 17 | A few days before the event, flyers were posted in Genentech Hall and |
| | 18 | other buildings at the Mission Bay Campus. Over 100 people attended |
| | 19 | to learn about Chimera and to enjoy pizza and other refreshments. |
| | 20 | Chimera was demonstrated on Mac and Windows computers, both connected |
| | 21 | to projectors. Handout materials summarized reasons to try Chimera as a |
| | 22 | new user, or to upgrade to the new version from prior versions. Also |
| | 23 | handed out were red-cyan stereo glasses, to work with the anaglyph display |
| | 24 | option, and a short survey about experiences with Chimera and other |
| | 25 | visualization software. 106 surveys were retrieved. |
| | 26 | - all Chimera team members |
| | 27 | |
| | 28 | Jul 16, 2007 |
| | 29 | "What's New in Chimera presentation" - Babbitt group, UCSF (~15 attendees) |
| | 30 | Advanced features were shown using live demonstrations accompanied by |
| | 31 | an HTML outline and linked pages. The emphasis was on recently added |
| | 32 | or improved features, including: raytracing, presets, red-cyan stereo, |
| | 33 | movie recording options, morphing, clash detection, assignment of charges |
| | 34 | and other parameters, minimization, rotamer libraries, and sequence |
| | 35 | alignment editing. The web materials were added to the Babbitt group |
| | 36 | wiki (private). |
| | 37 | - Elaine Meng and Eric Pettersen |
| | 38 | |
| | 39 | Aug 13, 2007 |
| | 40 | "Introduction to Molecular Visualization" Tutorial at the |
| | 41 | Computational Systems Bioinformatics (CSB) conference - |
| | 42 | University of California, San Diego (8 attendees). |
| | 43 | Abstract: |
| | 44 | Projects such as Structural Genomics are providing increasing numbers |
| | 45 | of experimental protein and protein-complex structures. Furthermore, |
| | 46 | increasing numbers of theoretical models are being predicted from |
| | 47 | primary sequence. Biologists have an increasing need to understand and |
| | 48 | communicate the structures, functions and relationships between these |
| | 49 | protein and protein-complex structures. As a result, molecular |
| | 50 | visualization is becoming an important tool for the presentation and |
| | 51 | communication of the results of biological experiments and research. |
| | 52 | This tutorial will provide a basic foundation for the understanding of |
| | 53 | molecular structures through use of visualization tools. |
| | 54 | Attendees will learn the basics of molecular visualization and will be |
| | 55 | provided an overview of available tools and techniques for visualization, |
| | 56 | analysis and modeling of protein structure. To make these concepts more |
| | 57 | concrete, attendees will be shown the academic program UCSF Chimera in |
| | 58 | more detail, and receive instruction in its features and use. |
| | 59 | The field of structural biology is still changing, and new techniques |
| | 60 | are continually being developed. Attendees will be shown how they can |
| | 61 | add new analysis techniques and their own data to the visualization. |
| | 62 | - Scooter Morris and Conrad Huang |
| | 63 | |
| | 64 | Oct 22, 2007 |
| | 65 | Two 20-min presentations on work done at the RBVI (each to 8 students) |
| | 66 | as part of an annual colloquium sponsored by the NSF's Alliances for |
| | 67 | Graduate Education and the Professoriate (AGEP). An example research |
| | 68 | scenario was illustrated with live demonstrations of Cytoscape and Chimera. |
| | 69 | AGEP's mission is to increase the number of underrepresented minority |
| | 70 | students who pursue graduate degrees and careers in the sciences and |
| | 71 | academia. The Colloquium is a two-day outreach and informational event |
| | 72 | that brings underrepresented undergraduate students to UCSF to learn |
| | 73 | about our graduate programs. This year's focus was on programs in |
| | 74 | Biophysics, Bioinformatics, and Systems Biology. |
| | 75 | - Scooter Morris and Elaine Meng |
| | 76 | |
| | 77 | Nov 3, 2007 |
| | 78 | UCSF School of Pharmacy Homecoming lab tours - presentations to groups |
| | 79 | of 14 and ~30 alumni on projects of the RBVI, including demonstrations |
| | 80 | of Cytoscape and Chimera. |
| | 81 | - Scooter Morris |
| | 82 | |
| | 83 | Nov 14, 2007 |
| | 84 | 30-min demo "Interactive Map Visualization with UCSF Chimera" |
| | 85 | at the NRAMM (National Resource for Automated Molecular Microscopy) |
| | 86 | Workshop on advanced topics in EM structure determination, |
| | 87 | November 10-16, 2007, The Scripps Research Institute, La Jolla, CA. |
| | 88 | http://nramm.scripps.edu/seminars/2007/cryoem/ |
| | 89 | - Tom Goddard |
| | 90 | |
| | 91 | December 6, 2007 |
| | 92 | Chimera Release Party and RBVI Open House (2-5 pm in Genentech Hall N453, |
| | 93 | UCSF Mission Bay) for local researchers and students to meet the Chimera |
| | 94 | developers, see demonstrations and discuss features, tour the RBVI |
| | 95 | facilities, and share refreshments. |
| | 96 | - Chimera team |
| | 97 | |
| | 98 | December 17, 2007 |
| | 99 | Chimera demonstration for Greg Farrington, executive director of the |
| | 100 | California Academy of Sciences, and Bruce Alberts, professor of |
| | 101 | biochemistry and biophysics, UCSF. |
| | 102 | - Tom Goddard |
| | 103 | |
| | 104 | Feb 3-5, 2008 |
| | 105 | Chimera demonstrations at the NCRR booth, 2008 Biophysical Society |
| | 106 | Annual Meeting, Long Beach, CA. Summaries: |
| | 107 | |
| | 108 | Title: Introduction to the UCSF Chimera molecular modeling package |
| | 109 | Presenter: Scooter Morris |
| | 110 | Abstract: |
| | 111 | UCSF Chimera is a program for interactive molecular graphics and modeling. |
| | 112 | It provides standard graphics features as well as more unique, domain-specific |
| | 113 | tools; the menu and command-line interfaces provide a rich and overlapping |
| | 114 | set of functionality. The Introduction to Chimera shows frequently used |
| | 115 | coloring and display options, including molecular representations such as |
| | 116 | ribbons, "pipes and planks," surfaces, and abstract renderings of nucleotides. |
| | 117 | Other general features shown are distance measurements, bond angle rotations, |
| | 118 | H-bond identification, and display of the corresponding amino acid and/or |
| | 119 | nucleotide sequences. Attributes such as B-factors and hydrophobicities can be |
| | 120 | rendered visually with colors, atomic radii, and "worm" thickness. |
| | 121 | Chimera includes detailed user documentation and is available for Windows, |
| | 122 | Linux, Mac OS X (with X11), IRIX, and Tru64 Unix. Chimera is free for |
| | 123 | academic, government, and non-profit use and can be downloaded from |
| | 124 | http://www.cgl.ucsf.edu/chimera |
| | 125 | |
| | 126 | Title: New Features in UCSF Chimera |
| | 127 | Presenter: Elaine Meng, Eric Pettersen |
| | 128 | Abstract: |
| | 129 | UCSF Chimera is an interactive molecular graphics program with a wide |
| | 130 | variety of features. Applications include structure analysis (hydrogen |
| | 131 | bonding, contacts, clashes), structure superposition and comparison, |
| | 132 | ensemble analysis (trajectory playback, ensemble clustering), analysis in |
| | 133 | the context of other types of data (sequence alignments, density maps), |
| | 134 | and making high-quality images and movies. |
| | 135 | |
| | 136 | Recently added features include display and incorporation of amino acid |
| | 137 | sidechain rotamers from backbone-dependent and -independent libraries, |
| | 138 | creation of "morph trajectories" between different conformations of a protein |
| | 139 | or even different proteins, and generating shadowed images with POV-Ray, |
| | 140 | which is embedded in Chimera. We will demonstrate these features as well |
| | 141 | as other features (whether new or not) upon request. |
| | 142 | |
| | 143 | Title: Visualizing 3-D Electron Microscopy Data with UCSF Chimera |
| | 144 | Presenter: Thomas Goddard |
| | 145 | Abstract: |
| | 146 | I'll demonstrate some new capabilities of the UCSF Chimera visualization |
| | 147 | program ( www.cgl.ucsf.edu/chimera) including tracing surfaces of intracellular |
| | 148 | membranes or virus layers in electron microscopy density maps, extracting |
| | 149 | density within surfaces, slicing tomography data at arbitrary angles to |
| | 150 | show nuclear pores, and displaying data cross-sections as topographic |
| | 151 | relief surfaces. |
| | 152 | |
| | 153 | UCSF Chimera is an interactive molecular graphics program for analysis of |
| | 154 | proteins, nucleic acids, volumetric and sequence data. and for creating |
| | 155 | publication images. The density map display and analysis capabilities are |
| | 156 | being developed for studying single particle reconstructions and EM tomography. |
| | 157 | |
| | 158 | Feb 6, 2008 |
| | 159 | Chimera presentation for discussion session on tomographic software, |
| | 160 | National Center for X-ray Tomography, Lawrence Berkeley National |
| | 161 | Laboratory, CA. |
| | 162 | - Tom Goddard |
| | 163 | |
| | 164 | Apr 4, 2008 |
| | 165 | Chimera demonstration showing electron microscopy data and crowded |
| | 166 | cellular environments to three high school visitors. |
| | 167 | - Tom Goddard |
| | 168 | |
| | 169 | Apr 14, 2008 |
| | 170 | Chimera demonstration for post-doc and programmer from the National |
| | 171 | Center for X-ray Tomography (at LBNL), showing stereo visualization, |
| | 172 | force feedback and 3D input devices, head tracking, and lenticular images. |
| | 173 | - Tom Goddard |
| | 174 | |
| | 175 | Apr 17, 2008 |
| | 176 | Demonstration of Chimera to a dozen students from Lincoln High School. |
| | 177 | - Tom Goddard |
| | 178 | |
| | 179 | Apr 24, 2008 |
| | 180 | Kids at UCSF Day. Two 90-minute sessions with up to 10 elementary- and |
| | 181 | middle-school-age children, on the theme: "What causes colds and flu? |
| | 182 | See, hold and feel these bugs using 3 dimensional computer virtual reality." |
| | 183 | Interactive molecular graphics with Chimera and paper models of |
| | 184 | viral capsids will be used. |
| | 185 | - Tom Goddard, Elaine Meng |
| | 186 | --------------------------------------------------------------------------- |
| | 187 | |