= ChimeraX Developer Meeting =

Attendance: Zach, Eric, Tom, Greg

April 13, 2026

= Agenda =

* macOS 27 is last support Intel apps
* Switch from !PySide to PyQt.
* Progress on !DockerHub ChimeraX.
* Inside ribbon color?
* Toolshed reduce query result size.
* [https://github.com/olibclarke/chimerax-resnotes Residue notes in mmCIF], Oliver Clarke
* Chimera not working with macOS 26, graphics pane positioned over command-line.
* Work in progress reports
* Make Chimera end-of-life bug report and registration changes.

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= Discussion =

* macOS 27 is last support Intel apps
 - Chimera won't work with macOS 28 (Fall 2027), 1.5 years from now.
 - It would probably be difficult to compile Chimera for Mac ARM since its Python packages predate Apple Silicon.
 - Users of older macOS will still be able to use Chimera, but new Macs or ones that are updated to macOS 28 will have to migrate to ChimeraX.
 - At some point after macOS 28 it may be difficult to build the Intel ChimeraX if Apple discontinues support for compiling to Intel.

* Switch from !PySide to PyQt.
 - Zach switched the daily build to PyQt last week.
 - So far no unusual PyQt bugs have been reported.
 - Plan is to distribute ChimeraX 1.12 with PyQt.

* Progress on !DockerHub ChimeraX.
 - Zach has ChimeraX compiling for Docker.
 - Will make a DockerHub image by next Monday's ChimeraX meeting.

* [https://github.com/olibclarke/chimerax-resnotes Residue notes in mmCIF], Oliver Clarke
 - Oliver Clarke made a ChimeraX GUI to create and save residue notes in mmCIF files.
 - His code is on github with installation instructions.
 - Oliver originally asked if we would include this feature in the ChimeraX distribution.
 - Tom will suggest he distribute his GUI on Toolshed instead.

* Coding potholes
 - Tom described spending 3 hours debugging an off by one pixel error in QGraphicsView for mutation heatmaps.
 - Eric described spending days to track down an unsigned int comparison to -1 that broke. the ported C++ match align code.

* Mutation heatmap command
 - Discussed how a mutation heatmap command can refer to different heatmap plots.
 - Eric says sequence alignment ids are associated with the alignment data, not with the alignment GUI.
 - User is likely to want several heatmap plots with different visualization settings (colormaps, residue choices, mutation scores choice...).
 - Command should probably be able to control those heatmap visualizations by naming the plots which is a new mechanism not used with other ChimeraX data.

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= Action Items =