[Chimera-users] Aligning homdimers

James Nettles nettlesconsulting at gmail.com
Tue Apr 4 04:16:46 PDT 2023


I’m asking a question that has been asked and answered before in 2009 - but not with exact  solution that I would like.

I have a relatively small homo dimer( <200 residue) and would like to fit with a homo dimer of the almost same sequence but slightly different conformations. I would like to fit the dimers as a pair (A/B to A/B)  rather than A to A and B to B separately. 

In other word, I’m wanting to spread the deviation across both monomer units  of the dimer in a single step rather than fitting separately and then recombining. 

I know Chimera isn’t formally supported any more, but I’m running this on an old machine with an old OS , so ChimeraX isn’t an option here. 

Thanks so much in advance - this group has always bee fabulous over the years. 

Best regards,

Jim 





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