[Chimera-users] Request for assistance

[Zachary W. Carpenter]

Dear Chimera,
I have been a long time user and really love your software. Recently I have
used and cited Chimera in 4 high impact publications. One in mBio, two in
nature medicine, and a final one in review at Nature Genetics. I have used
Chimera to make beautiful images of mutations that we identify in NGS data
of tumors. My role has become interpreting the effects of mutations on
crystal structure. Thus far this has not been difficult as the effects of
the mutations have been obvious. A recent finding however has left me
extremely perplexed and I have need for greater accuracy of structural
modeling of the mutations. I was wondering if you can put me in the right
direction for creating models of mutations that are more reliable then just
using Modeller or I-Tasser with the mutant in the sequence to be predicted.
I know this is an elaborate question but I'd like to know which Chimera
tools I can use to help me along this path. Or if I need to use totally new
software/ methods.

Thanks for your time,
Zach


-- 
Zachary W. Carpenter
Department of Pharmacology
College of Physicians and Surgeons
Columbia University
630 West 168th Street
New York, NY 10032

Email: ZWC2101 at Columbia.edu
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