[Chimera-users] Ringer: A program to detect molecular motions by systematic X-ray electron-density sampling

[Terry Lang]

The Alber lab at UC Berkeley is pleased to release of the code for 
Ringer version 1.0 (http://ucxray.berkeley.edu/ringer.htm), which 
depends on Chimera.  Ringer is a program to detect molecular motions by 
systematic X-ray electron-density sampling. The aim of Ringer is to go 
beyond static structural snapshots of proteins by uncovering structural 
ensembles in X-ray electron density. This information can reveal not 
only which parts of proteins are flexible and which parts are rigid, but 
it also can define alternate conformations that may be important for 
function. Alternate conformations of binding sites also may afford 
additional targets for drug design.  The Ringer method is described in 
Lang et al. /Protein Sci/. 2010 Jul; 19(7):1420-31 
<http://www.ncbi.nlm.nih.gov/pubmed/20499387>.  An application of 
Ringer, determining the structural underpinnings of the side chain 
dynamics critical for the function of the enzyme proline isomerase, was 
published in Fraser JS et al. /Nature/. 2009 Dec 3;462(7273):669-73 
<http://www.ncbi.nlm.nih.gov/pubmed/19956261>.  Ringer is freely 
available to academics.

-- 
PaulaTherese Lang
Postdoctoral Scholar
Alber Lab, UC Berkeley
http://ucxray.berkeley.edu/ringer.htm