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<div>Thank you for your response -- Sincerely, Craig Scoville<br></div><div><br></div>
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On Thursday, January 31, 2019, 11:02:37 AM MST, Elaine Meng <meng@cgl.ucsf.edu> wrote:
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<div><div dir="ltr">Dear Dr. Scoville,<br clear="none">(I changed the subject line because “question” is not useful to people searching for a topic) <br clear="none"><br clear="none">You can build peptides, but it will not do conformational analysis for you. I.e. you would get “a” shape but Chimera wouldn’t automatically figure out the range of possible shapes (since peptides are quite flexible) or which shapes would predominate.<br clear="none"><br clear="none">Besides peptide building, there is general structural analysis: you can rotate bonds, measure distances, show molecular surface, measure surface area and enclosed volume, etc. There is a full user manual with tutorials,<br clear="none"><<a shape="rect" href="http://www.rbvi.ucsf.edu/chimera/docs/UsersGuide/index.html" rel="nofollow" target="_blank">http://www.rbvi.ucsf.edu/chimera/docs/UsersGuide/index.html</a>><br clear="none"><<a shape="rect" href="http://www.rbvi.ucsf.edu/Outreach/Tutorials/GettingStarted.html" rel="nofollow" target="_blank">http://www.rbvi.ucsf.edu/Outreach/Tutorials/GettingStarted.html</a>><br clear="none">...and you can search for terms of interest with the menu: Help… Search Documentation. <br clear="none"><br clear="none">Chimera is free for noncommercial use. For commercial use, contact <a shape="rect" href="mailto:chimera@cgl.ucsf.edu" rel="nofollow" target="_blank">chimera@cgl.ucsf.edu</a><br clear="none">Licensing:<br clear="none"><<a shape="rect" href="http://www.rbvi.ucsf.edu/chimera/docs/licensing.html" rel="nofollow" target="_blank">http://www.rbvi.ucsf.edu/chimera/docs/licensing.html</a>><br clear="none"><br clear="none">I hope this helps,<br clear="none">Elaine<br clear="none">-----<br clear="none">Elaine C. Meng, Ph.D.<br clear="none">UCSF Chimera(X) team<br clear="none">Department of Pharmaceutical Chemistry<br clear="none">University of California, San Francisco<br clear="none"><div class="ydp464884f5yqt1511969308" id="ydp464884f5yqtfd25908"><br clear="none">> On Jan 30, 2019, at 3:28 PM, Craig Scoville <<a shape="rect" href="mailto:cdscoville@yahoo.com" rel="nofollow" target="_blank">cdscoville@yahoo.com</a>> wrote:<br clear="none">> <br clear="none">> Dear Staff -- I am interested in using Chimera but have a question regarding its use. I am interested in looking at the shape of small polypeptides --usually ranging from 5-20 amino acids -- does this program allow me to input amino acid sequences and then look at confirmational shapes? make substitutions and then compare confirmational shapes? Does the proprietary nature of my work prohibit me from using Chimera? Sincerely, Dr Scoville<br clear="none"></div></div></div>
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