<html><head></head><body><div class="ydp1a7dd126yahoo-style-wrap" style=""><p class="ydpcc6eb141MsoNormal" style="font-family: Helvetica Neue, Helvetica, Arial, sans-serif; font-size: 16px; margin-bottom: 0.0001pt; line-height: normal; background: white;"><span style="font-size:10.0pt;font-family:Helvetica,sans-serif;mso-fareast-font-family:Times New Roman;color:black">Dear Chimera Users,</span></p>
<p class="ydpcc6eb141MsoNormal" style="font-family: Helvetica Neue, Helvetica, Arial, sans-serif; font-size: 16px; margin-bottom: 0.0001pt; line-height: normal; background: white;"><span style="font-size:10.0pt;font-family:Helvetica,sans-serif;mso-fareast-font-family:Times New Roman;color:black"> </span></p>
<p class="ydpcc6eb141MsoNormal" style="font-family: Helvetica Neue, Helvetica, Arial, sans-serif; font-size: 16px; margin-bottom: 0.0001pt; line-height: normal; background: white;"><span style="font-size:10.0pt;font-family:Helvetica,sans-serif;mso-fareast-font-family:Times New Roman;color:black">I am studying on a
protein and its interactions with its ligands and I want to explore what would
be the effect on protein thermodynamic stability if some parameters were changed such as
addition, removal of hydrogen bonds or other forces. Any idea on how to do
that? I am new on this.</span></p>
<p class="ydpcc6eb141MsoNormal" style="font-family: Helvetica Neue, Helvetica, Arial, sans-serif; font-size: 16px; margin-bottom: 0.0001pt; line-height: normal; background: white;"><span style="font-size:10.0pt;font-family:Helvetica,sans-serif;mso-fareast-font-family:Times New Roman;color:black"> </span></p>
<p class="ydpcc6eb141MsoNormal" style="font-family: Helvetica Neue, Helvetica, Arial, sans-serif; font-size: 16px; margin-bottom: 0.0001pt; line-height: normal; background: white;"><span style="font-size:10.0pt;font-family:Helvetica,sans-serif;mso-fareast-font-family:Times New Roman;color:black">Thank you on advance!</span></p>
<p class="ydpcc6eb141MsoNormal" style="font-family: Helvetica Neue, Helvetica, Arial, sans-serif; font-size: 16px; margin-bottom: 0.0001pt; line-height: normal; background: white;"><span style="font-size:10.0pt;font-family:Helvetica,sans-serif;mso-fareast-font-family:Times New Roman;color:black"> </span></p>
<p class="ydpcc6eb141MsoNormal" style="font-family: Helvetica Neue, Helvetica, Arial, sans-serif; font-size: 16px; margin-bottom: 0.0001pt; line-height: normal; background: white;"><span style="font-size:10.0pt;font-family:Helvetica,sans-serif;mso-fareast-font-family:Times New Roman;color:black"> </span></p>
<p class="ydpcc6eb141MsoNormal" style="margin-bottom: 0.0001pt; line-height: normal; background: white;"><font face="Helvetica, sans-serif"><span style="font-size: 13.3333px;">Kloe</span></font> <br></p></div></body></html>