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<blockquote type="cite" style="font-size:12.8px;text-decoration-style:initial;text-decoration-color:initial"><div dir="ltr"><span style="font-size:12.8px;text-decoration-style:initial;text-decoration-color:initial;float:none;display:inline">Hello </span><br style="font-size:12.8px;text-decoration-style:initial;text-decoration-color:initial"><span style="font-size:12.8px;text-decoration-style:initial;text-decoration-color:initial;float:none;display:inline">Thanks a lot for your effort</span><br style="font-size:12.8px;text-decoration-style:initial;text-decoration-color:initial"><span style="font-size:12.8px;text-decoration-style:initial;text-decoration-color:initial;float:none;display:inline">please help me to know how can I determine My Model for a certain mutated gene</span><br style="font-size:12.8px;text-decoration-style:initial;text-decoration-color:initial"><span style="font-size:12.8px;text-decoration-style:initial;text-decoration-color:initial;float:none;display:inline">(like smn protein for normal sequences,type I,II,III,and IV Spinal muscular atrophy)</span><br style="font-size:12.8px;text-decoration-style:initial;text-decoration-color:initial"><span style="font-size:12.8px;text-decoration-style:initial;text-decoration-color:initial;float:none;display:inline">How can I know the protein model for different seq is functional or non functional?</span><br style="font-size:12.8px;text-decoration-style:initial;text-decoration-color:initial"><span style="font-size:12.8px;text-decoration-style:initial;text-decoration-color:initial;float:none;display:inline">I made models for different affected cases of SMA with A suitable template for pdb  and Recorded The Qmean and GMQE number for each model with but till now I can not be able to determine this sequence produce good functional protein or not</span><br style="font-size:12.8px;text-decoration-style:initial;text-decoration-color:initial"><span style="font-size:12.8px;text-decoration-style:initial;text-decoration-color:initial;float:none;display:inline">especially with gene have Frame shift mutation which produce new protein and also have a lot of stop codon in the sequence</span><br style="font-size:12.8px;text-decoration-style:initial;text-decoration-color:initial"><span style="font-size:12.8px;text-decoration-style:initial;text-decoration-color:initial;float:none;display:inline">I hope you understand the meaning of  my Question ? and hope to guide me to suitable tool or method</span><br style="font-size:12.8px;text-decoration-style:initial;text-decoration-color:initial"><span style="font-size:12.8px;text-decoration-style:initial;text-decoration-color:initial;float:none;display:inline">Thanks</span></div></blockquote>

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