<div dir="ltr"><div>Hello,<br></div><div>recently I was looking into the capabilities of Chimera minimization tools to minimize the structure of a DNA G-<span style class="">quadruplex</span> molecule.<br></div><div>The problem is that all G-<span style class="">quadruplexes</span> have an ion (K+ or Na+) in-between and stabilizing the <span style class="">tetrads</span>. I wonder if the force field available in chimera are "decent" to water-minimize this kind of structures? ...and which one is more adapted, after all those are non-conventional DNA structures.<br>
</div><div>Thanks in advance for your input<br> </div><div><br><span style class="">Gilmar</span> <span style class="">Salgado</span><br><br><span style class="">Université</span> <span style class="">Segalen</span> <br><span style class="">Laboratoire</span> <span style class="">ARNA</span> (<span style class="">INSERM</span> U869)<br>
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