[Chimera-users] error code -1073741819

Tom Goddard goddard at sonic.net
Tue Mar 9 10:54:27 PST 2021

Hi Beni,

The gzip message is just misleading.  It is not an error and is explained here


The real problem is almost surely that your graphics driver is broken since it gets to "Initializing graphics" and then dies.  Updating the graphics driver was the right thing to try.

One other remote possibility is that some Chimera preference setting is causing startup to fail -- like maybe you enabled multisampling in the past and the new graphics driver wipes out whenever you try to use it.  The location of preferences is


(from documentation here https://www.cgl.ucsf.edu/chimera/docs/UsersGuide/preferences.html <https://www.cgl.ucsf.edu/chimera/docs/UsersGuide/preferences.html>).  You might rename that .chimera folder so Chimera starts with factory default preferences and try to start.


> On Mar 7, 2021, at 1:18 PM, Beni Sued <benisued at gmail.com> wrote:
> Hey there 
> I've been using UCSF chimera for some time with no problems but it is having trouble starting up, this is the error message:
> Cannot execute 'gzip': no automatic decompression of .Z files
> initializing general preferences
> loading Tix
> initializing graphics
> Return code: -1073741819
> Press return or enter to to exit
> precisely like this gentleman:
> https://plato.cgl.ucsf.edu/pipermail/chimera-users/2019-April/015675.html <https://plato.cgl.ucsf.edu/pipermail/chimera-users/2019-April/015675.html>
> and this 
> https://www.cgl.ucsf.edu/pipermail/chimera-users/2011-December/007021.html <https://www.cgl.ucsf.edu/pipermail/chimera-users/2011-December/007021.html>
> my dxdiag info is attached, nothing wrong jumps to me.
> What I've tried:
> - uninstalling and reinstalling Chimera
> - manually installing GZIP for windows  ( https://sourceforge.net/projects/gzip-for-windows/ <https://sourceforge.net/projects/gzip-for-windows/> )
> - updating drivers (graphics drivers and chipset drivers)
> - getting the alpha version of the program
> - going to and fro compute mode in the the graphical settings
> I'm using Chimera 1.15 and this is my hardware
> chipset b550m
> ryzen 5600x
> RX 590
> in trying to fix it I learned about ChimeraX, I'm learning to use it, but I would still like to keep chimera until i can properly stop and change my workflow
> thanks so much, let me know if I missed any info
> <DxDiag.txt>_______________________________________________
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