[Chimera-users] Constructing a biological assembly in Chimera

Elaine Meng meng at cgl.ucsf.edu
Mon Apr 8 09:12:14 PDT 2019

Hello Ahmad,
There is no feature to automatically apply any changes in one monomer to all the other monomers.  As far as I know, you would need to first modify the monomer and then create the biological assembly of the modified monomer.

If you already have the biological assembly of the unmodified monomer, another possibility is to open several copies of modified one and match them onto the unmodified ones (possibly by writing your own script to do it since I imagine it would be a lot of repetitious commands), and then close the unmodified ones.  However, that might be more work than just using the modified monomer to make the assembly in the first place, and might give a slightly different result.

I hope this helps,
Elaine C. Meng, Ph.D.
UCSF Chimera(X) team
Department of Pharmaceutical Chemistry
University of California, San Francisco

> On Apr 7, 2019, at 6:07 AM, Ahmad Khalifa <underoath006 at gmail.com> wrote:
> Hello,
> I'm working with a lattice made of a tubulin monomer that I modeled and refined in Coot. 
> I have fitted other units of the monomer along the length and to the side of my monomer in a cryo-EM map to study tubulin interactions with non tubulin proteins.
> Instead, I wonder if I can construct a biological assembly of just one unit, to have any modifications or changes in that unit reflected in the entire biological assembly.
> Any other help or suggestions would be appreciated. 
> Regards. 

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