[Chimera-users] electrostatic potential based on Swiss-Model
arolni at umich.edu
Thu Jun 5 13:07:54 PDT 2014
I am a graduate student at the University of Michigan and I am currently
trying to obtain images of my proteins with electrostatic potentials for my
manuscript. For one of my proteins, there is no solved protein structure
(by X-ray crystallography or NMR) and I had to use SWISS-MODEL to predict
the structure. I did electrostatic potential calculation using DelPhi but
when I visualized it using Chimera, the electrostatic distribution is not
what I expected. I did notice the electrostatic potential calculations for
other previously solved protein structures took much longer and resulted in
bigger files, whereas the SWISS-MODEL-predicted protein contains much
smaller .phi file size.
I was wondering if you have any idea how accurate it is to calculate the
electrostatic potential based on a SWISS-MODEL predicted protein structure,
and if there are ways to improve the reliability of the calculated
electrostatic potentials for that protein?
Thank you very much for your help!
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