[Chimera-users] using modeller through chimera

[Elaine Meng]

Hi Taufiq,
It is probably disabled because you are viewing a single sequence rather than an alignment of 2 or more sequences.  In Chimera, there are several ways to get the needed inputs for Modeller, which include the sequence alignment and a structure to use as the template.  Some ways are outlined here:

<http://www.cgl.ucsf.edu/chimera/docs/ContributedSoftware/multalignviewer/multalignviewer.html#approaches>

Once you have the inputs, you can run Modeller either via web service or via your local installation. If you haven't already, you would also need to obtain a Modeller license key before running (even if you are going to use the web service).

I would also recommend that you get a newer version of Chimera (at least 1.6.2). The Modeller interface is improved in that version compared to older versions.  The sequence window menu will then include both "Structure... Modeller (homology)" and "... Modeller (loops/refinement)" instead of a single "...Modeller Tools" entry.

This documentation is for 1.6.2:
<http://www.cgl.ucsf.edu/chimera/docs/ContributedSoftware/multalignviewer/modeller.html>

I hope this helps,
Elaine
-----
Elaine C. Meng, Ph.D.                       
UCSF Computer Graphics Lab (Chimera team) and Babbitt Lab
Department of Pharmaceutical Chemistry
University of California, San Francisco

On Oct 2, 2012, at 7:49 AM, Taufiq Rahman wrote:

> Hello, I want to use modeller through Chimera's interface. I have seen the video and read about the way to do it. My problem is my 'modeller tool' option in the structure menu remains disabled. I have installed modeller locally but don't know how to integrate it into chimera.
> 
> any suggestion?
> 
> taufiq