Clustal Conservation Groups

The clustal format read and written by Multalign Viewer includes characters symbolizing degree of conservation.

Positions where every residue is the same type (complete identity) are marked with an asterisk (*).

Positions where one of the following strong groups is fully conserved are marked with a colon (:).

STA  
NEQK  
NHQK  
NDEQ  
QHRK  
MILV  
MILF  
HY  
FYW

Positions where one of the following weak groups is fully conserved are marked with a period (.).

CSA  
ATV  
SAG  
STNK  
STPA  
SGND  
SNDEQK  
NDEQHK  
NEQHRK  
FVLIM  
HFY

The groups are defined using the PAM250 matrix; scores within the strong groups are over 0.5 and scores within the weak groups are positive but no greater than 0.5.

Other positions are not marked with any character.

UCSF Computer Graphics Laboratory / April 2003