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Bluetongue Virus and Viral RNA

Contacts between capsid and RNA

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Bluetongue virus with viral RNA

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Bluetongue virus infects cattle, sheep and goats and has caused epidemics effecting millions of animals with large economic impact. This crystal structure shows the virus capsid with viral RNA sticking to the outside. The stickiness is thought to sequester viral RNA preventing an immune response in host cells. Atomic contacts between RNA and capsid within 5 angstroms are shown in black in the upper image. The virus capsid is Protein Data Bank model 2btv, and the viral RNA is model 1h1k. For more information see Diprose, et al, J Virol. 2002 Sep;76(18):9533-6.

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